Interchangeability between 24-hour collection and single spot urines for vanillylmandelic and homovanillic acid levels in the diagnosis of neuroblastoma

Giuliana Cangemi, Sebastiano Barco, Giorgio Reggiardo, Elisabetta Viscardi, Andrea Di Cataldo, Alberto Garaventa, Giovanni Melioli, Massimo Conte

Research output: Contribution to journalArticlepeer-review

Abstract

The determination of the two urinary catecholamine metabolites homovanillic acid (HVA) and vanillylmandelic acid (VMA) is of crucial importance for the diagnosis and follow-up of neuroblastoma (NB). The standard practice for their measurement requires the use of 24-hour collections that are time consuming and difficult to obtain. In this article, we directly demonstrate that 24-hour collections and single spot urines are interchangeable for the determination of HVA and VMA expressed as ratio on creatinine concentration. This study can be useful for a faster management of NB at onset. Pediatr Blood Cancer 2013;60:E170-E172.

Original languageEnglish
JournalPediatric Blood and Cancer
Volume60
Issue number12
DOIs
Publication statusPublished - Dec 2013

Keywords

  • 24-hour collection
  • Homovanillic acid
  • Neuroblastoma
  • Single spot urine
  • Vanillylmandelic acid

ASJC Scopus subject areas

  • Oncology
  • Pediatrics, Perinatology, and Child Health
  • Hematology

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