Intereleukin-10 promoter polymorphism in mild cognitive impairment and in its clinical evolution

Giorgio Annoni, Beatrice Arosio, Luigina Mastronardi, Carlo Vergani

Research output: Contribution to journalArticle

Abstract

Specific proinflammatory alleles are associated with higher risk of Alzheimer disease (AD) in different onset age. The homozygosis for the A allele of -1082 polymorphism (G/A) of interleukin-10 (IL-10) promotes a higher risk of AD and reduced IL-10 generation in peripheral cells after amyloid stimulation. In this paper we analysed genotype and allele frequencies of this polymorphism in 138 subjects with mild cognitive impairment (MCI) diagnosed, respectively, as amnestic (a-MCI) and multiple impaired cognitive domains (mcd-MCI). The genotype frequencies were similar in a-MCI and AD subjects, whereas in mcd-MCI comparable to controls (AA genotype: 50 in a-MCI, 49.2 in AD, 28.7 in mcd-MCI and 31.8 in controls). Consequently, both allele and genotype distributions were significantly different between a-MCI and mcd-MCI (allele: P =.02, genotype: P

Original languageEnglish
Article number854527
JournalInternational Journal of Alzheimer's Disease
DOIs
Publication statusPublished - 2010

ASJC Scopus subject areas

  • Clinical Neurology
  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Ageing
  • Cellular and Molecular Neuroscience
  • Neurology

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