TY - JOUR
T1 - Intereleukin-10 promoter polymorphism in mild cognitive impairment and in its clinical evolution
AU - Annoni, Giorgio
AU - Arosio, Beatrice
AU - Mastronardi, Luigina
AU - Vergani, Carlo
PY - 2010
Y1 - 2010
N2 - Specific proinflammatory alleles are associated with higher risk of Alzheimer disease (AD) in different onset age. The homozygosis for the A allele of -1082 polymorphism (G/A) of interleukin-10 (IL-10) promotes a higher risk of AD and reduced IL-10 generation in peripheral cells after amyloid stimulation. In this paper we analysed genotype and allele frequencies of this polymorphism in 138 subjects with mild cognitive impairment (MCI) diagnosed, respectively, as amnestic (a-MCI) and multiple impaired cognitive domains (mcd-MCI). The genotype frequencies were similar in a-MCI and AD subjects, whereas in mcd-MCI comparable to controls (AA genotype: 50 in a-MCI, 49.2 in AD, 28.7 in mcd-MCI and 31.8 in controls). Consequently, both allele and genotype distributions were significantly different between a-MCI and mcd-MCI (allele: P =.02, genotype: P
AB - Specific proinflammatory alleles are associated with higher risk of Alzheimer disease (AD) in different onset age. The homozygosis for the A allele of -1082 polymorphism (G/A) of interleukin-10 (IL-10) promotes a higher risk of AD and reduced IL-10 generation in peripheral cells after amyloid stimulation. In this paper we analysed genotype and allele frequencies of this polymorphism in 138 subjects with mild cognitive impairment (MCI) diagnosed, respectively, as amnestic (a-MCI) and multiple impaired cognitive domains (mcd-MCI). The genotype frequencies were similar in a-MCI and AD subjects, whereas in mcd-MCI comparable to controls (AA genotype: 50 in a-MCI, 49.2 in AD, 28.7 in mcd-MCI and 31.8 in controls). Consequently, both allele and genotype distributions were significantly different between a-MCI and mcd-MCI (allele: P =.02, genotype: P
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U2 - 10.4061/2010/854527
DO - 10.4061/2010/854527
M3 - Article
C2 - 20798845
AN - SCOPUS:77956863647
JO - International Journal of Alzheimer's Disease
JF - International Journal of Alzheimer's Disease
SN - 2090-8024
M1 - 854527
ER -