Interference between anti HLA antibodies and chlorpromazine

E. Smeraldi, R. Scorza Smeraldi

Research output: Contribution to journalArticle

Abstract

It has been suggested that the effects of chlorpromazine in man and animals are genetically influenced. In mice, genetic control of sensitivity to this drug seems to reside in 2 loci, the more important of which lies on chromosome 9 at about the region which controls the histocompatibility system H2 (ref. 3). The authors have investigated whether the presence or absence of some alleles of the HLA system, analogous to the H2 system of mice, correlate with individual sensitivity to the drug. They evaluated the clinical responses to chlorpromazine of 33 chronic schizophrenic subjects who had been HLA typed during previous investigations. There was a highly significant positive response to chlorpromazine in patients with the antigen HLA-A1 of the HLA-A locus (unpublished results of ES, L. Bellodi and E. Sacchetti). A possible explanation of the correlation is that the presence of HLA-A1 on the cell membrane makes chlorpromazine bind more readily to the cell. As chlorpromazine binds to lymphocyte membranes, they investigated whether or not the binding of the drug could interfere with the specific binding of anti-HLA antibodies, particularly anti-HLA-A1 antisera. Furthermore, as chlorpromazine binds to the β adrenergic cell receptors, which are also present on peripheral blood lymphocytes, the β adrenergic mediators dopamine (DA) and noradrenaline (NA) were used.

Original languageEnglish
Pages (from-to)532-533
Number of pages2
JournalNature
Volume260
Issue number5551
Publication statusPublished - 1976

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Chlorpromazine
Anti-Idiotypic Antibodies
HLA-A1 Antigen
Pharmaceutical Preparations
Chromosomes, Human, Pair 9
Histocompatibility
HLA-A Antigens
Lymphokines
Adrenergic Agents
Adrenergic Receptors
Immune Sera
Dopamine
Norepinephrine
Alleles
Cell Membrane
Lymphocytes
Membranes

ASJC Scopus subject areas

  • General

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Smeraldi, E., & Scorza Smeraldi, R. (1976). Interference between anti HLA antibodies and chlorpromazine. Nature, 260(5551), 532-533.

Interference between anti HLA antibodies and chlorpromazine. / Smeraldi, E.; Scorza Smeraldi, R.

In: Nature, Vol. 260, No. 5551, 1976, p. 532-533.

Research output: Contribution to journalArticle

Smeraldi, E & Scorza Smeraldi, R 1976, 'Interference between anti HLA antibodies and chlorpromazine', Nature, vol. 260, no. 5551, pp. 532-533.
Smeraldi E, Scorza Smeraldi R. Interference between anti HLA antibodies and chlorpromazine. Nature. 1976;260(5551):532-533.
Smeraldi, E. ; Scorza Smeraldi, R. / Interference between anti HLA antibodies and chlorpromazine. In: Nature. 1976 ; Vol. 260, No. 5551. pp. 532-533.
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