Interferences in estimation of free thyroid hormones with special reference to antiiodothyronine autoantibodies in serum

P. Beck-Peccoz, P. B. Romelli, M. G. Cattaneo

Research output: Contribution to journalArticle

Abstract

The interpretation of results from some 'new' free thyroid hormone measurement methods should be cautious, owing the high percentage of interferences present particularly in both indirect (Coming) and direct (Amerlex) methods. These artefacts may suggest hyper- or hypothyroidism when the patient is completely normal or may mask the presence of serious thyroid dysfunctions. From the present study is clear that highly reliable methods in assessing thyroid function are those able to avoid contact between serum proteins and tracer at the time of the assay. In this view, Lisophase seems to be more useful in comparison with equilibrium dialysis + RIA and Clinical Assays 2-step, as it is more rapid, reproducible and simple for the measurement of FT4 or FT3 concentrations.

Original languageEnglish
Pages (from-to)369-372
Number of pages4
JournalNUC Compact
Volume16
Issue number6
Publication statusPublished - 1985

Fingerprint

Thyroid Hormones
Autoantibodies
Thyroid Gland
Serum
Hyperthyroidism
Masks
Hypothyroidism
Artifacts
Blood Proteins
Dialysis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Interferences in estimation of free thyroid hormones with special reference to antiiodothyronine autoantibodies in serum. / Beck-Peccoz, P.; Romelli, P. B.; Cattaneo, M. G.

In: NUC Compact, Vol. 16, No. 6, 1985, p. 369-372.

Research output: Contribution to journalArticle

Beck-Peccoz, P. ; Romelli, P. B. ; Cattaneo, M. G. / Interferences in estimation of free thyroid hormones with special reference to antiiodothyronine autoantibodies in serum. In: NUC Compact. 1985 ; Vol. 16, No. 6. pp. 369-372.
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