TY - JOUR
T1 - Interferon-α,β and tumor necrosis factor-α enhance the freguency of miniature end-plate potentials at rat neuromuscular junction
AU - Caratsch, C. G.
AU - Santoni, A.
AU - Eusebi, F.
PY - 1994/1/17
Y1 - 1994/1/17
N2 - The effects of the two cytokines, rat interferon-α,β and human tumor necrosis factor-α, were studied at the rat neuromuscular junction by using classical electrophysiological techniques. Both cytokines in a similar way at concentrations of 2,000 and 35,000 U/ml, respectively, increased transiently and with a relatively long delay (15 to 25 min) the frequency of mimiature endplate potentials. The observed effects may be related to complex second messenger mechanisms and contribute to modulation and plasticity of neurotransmission.
AB - The effects of the two cytokines, rat interferon-α,β and human tumor necrosis factor-α, were studied at the rat neuromuscular junction by using classical electrophysiological techniques. Both cytokines in a similar way at concentrations of 2,000 and 35,000 U/ml, respectively, increased transiently and with a relatively long delay (15 to 25 min) the frequency of mimiature endplate potentials. The observed effects may be related to complex second messenger mechanisms and contribute to modulation and plasticity of neurotransmission.
KW - Electrophysiology
KW - Interferon
KW - Mammalian neuromuscular junction
KW - Neuromodulation
KW - Tumor necrosis factor
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U2 - 10.1016/0304-3940(94)90849-4
DO - 10.1016/0304-3940(94)90849-4
M3 - Article
C2 - 8190367
AN - SCOPUS:0028177999
VL - 166
SP - 97
EP - 100
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 1
ER -