Interferon-α,β and tumor necrosis factor-α enhance the freguency of miniature end-plate potentials at rat neuromuscular junction

C. G. Caratsch, A. Santoni, F. Eusebi

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of the two cytokines, rat interferon-α,β and human tumor necrosis factor-α, were studied at the rat neuromuscular junction by using classical electrophysiological techniques. Both cytokines in a similar way at concentrations of 2,000 and 35,000 U/ml, respectively, increased transiently and with a relatively long delay (15 to 25 min) the frequency of mimiature endplate potentials. The observed effects may be related to complex second messenger mechanisms and contribute to modulation and plasticity of neurotransmission.

Original languageEnglish
Pages (from-to)97-100
Number of pages4
JournalNeuroscience Letters
Volume166
Issue number1
DOIs
Publication statusPublished - Jan 17 1994

Keywords

  • Electrophysiology
  • Interferon
  • Mammalian neuromuscular junction
  • Neuromodulation
  • Tumor necrosis factor

ASJC Scopus subject areas

  • Neuroscience(all)

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