Low levels of anti-viral activity, mainly interteron α/β (IFN-α/β), are regularly found in lymphoid tissues of BALB/c mice infected with the C3H strain of mammary tumor virus. At the time of tumor development, significant amounts of anti-viral activity were detected in homogenates of spleen and mammary tumors, but not in blood and normal mammary glands. This activity is pH2-resistant and neutralized by antibody to IFN/α-β. The pathogenetic role of IFN in mammary carcinogenesis was investigated in 2 ways: (a) by treating virus-infected newborn mice with antibody to IFN-α/β, and (b) by giving either the latter antibody or IFN-α/β to virus-free animals transplanted with pre-neoplastic lesions. Mice were treated only for 2 months, starting either 1 week after birth or immediately after tumor transplant. In case (a), treatment with antibody to IFN-α/β shortened the incubation period of mammary carcinomas and decreased the mean survival time. In case (b), anti-IFN antibody did not significantly affect the development of mammary tumors. However, exogenous IFN-α/β markedly reduced both tumor incidence and mortality rate. These results indicate that endogenous IFN-α/β plays a crucial role in the in vivo restriction of the early infectious phase of spontaneous carcinogenesis and that relatively high doses of IFN-α/β may inhibit the progression of pre-neoplastic lesions.
|Number of pages||6|
|Journal||International Journal of Cancer|
|Publication status||Published - 1992|
ASJC Scopus subject areas
- Cancer Research