Interferon-α/β in virus-induced mouse mammary carcinogenesis: Effects on the spontaneous process and on the progression of transplanted pre-neoplastic lesions

F. Basolo, G. Fontanini, C. Serra, A. Dolei, E. Proietti, F. Belardelli, P. G. Conaldi, M. Bistocchi, F. Squartini, A. Toniolo

Research output: Contribution to journalArticle

Abstract

Low levels of anti-viral activity, mainly interteron α/β (IFN-α/β), are regularly found in lymphoid tissues of BALB/c mice infected with the C3H strain of mammary tumor virus. At the time of tumor development, significant amounts of anti-viral activity were detected in homogenates of spleen and mammary tumors, but not in blood and normal mammary glands. This activity is pH2-resistant and neutralized by antibody to IFN/α-β. The pathogenetic role of IFN in mammary carcinogenesis was investigated in 2 ways: (a) by treating virus-infected newborn mice with antibody to IFN-α/β, and (b) by giving either the latter antibody or IFN-α/β to virus-free animals transplanted with pre-neoplastic lesions. Mice were treated only for 2 months, starting either 1 week after birth or immediately after tumor transplant. In case (a), treatment with antibody to IFN-α/β shortened the incubation period of mammary carcinomas and decreased the mean survival time. In case (b), anti-IFN antibody did not significantly affect the development of mammary tumors. However, exogenous IFN-α/β markedly reduced both tumor incidence and mortality rate. These results indicate that endogenous IFN-α/β plays a crucial role in the in vivo restriction of the early infectious phase of spontaneous carcinogenesis and that relatively high doses of IFN-α/β may inhibit the progression of pre-neoplastic lesions.

Original languageEnglish
Pages (from-to)956-961
Number of pages6
JournalInternational Journal of Cancer
Volume51
Issue number6
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Basolo, F., Fontanini, G., Serra, C., Dolei, A., Proietti, E., Belardelli, F., Conaldi, P. G., Bistocchi, M., Squartini, F., & Toniolo, A. (1992). Interferon-α/β in virus-induced mouse mammary carcinogenesis: Effects on the spontaneous process and on the progression of transplanted pre-neoplastic lesions. International Journal of Cancer, 51(6), 956-961.