TY - JOUR
T1 - Interferon α and Tat involvement in the immunosuppression of uninfected T cells and C-C chemokine decline in AIDS
AU - Zagury, Daniel
AU - Lachgar, Abderrahim
AU - Chams, Vida
AU - Fall, Lat S.
AU - Bernard, Jacky
AU - Zagury, Jean François
AU - Bizzini, Bernard
AU - Gringeri, Alessandro
AU - Santagostino, Elena
AU - Rappaport, Jay
AU - Feldman, Michael
AU - Burny, Arsène
AU - Gallo, Robert C.
PY - 1998/3/31
Y1 - 1998/3/31
N2 - HIV type 1 (HIV-1) not only directly kills infected CD4+ T cells but also induces immunosuppression of uninfected T cells. Two immunosuppressive proteins, interferon α (IFNα) and extracellular Tat, mediate this process because specific antibodies against these proteins prevent generation of suppressor cells in HIV-1-infected peripheral blood mononuclear cell cultures. Furthermore, the production of C-C chemokines in response to immune cell activation, initially enhanced by IFNα and Tat, ultimately is inhibited by these proteins in parallel with their induction of immunosuppression. The clinical corollary is the immunosuppression of uninfected T cells and the decline in C-C chemokine release found at advanced stages of HIV-1 infection paralleling rising levels of IFNα and extracellular Tat. We, therefore, suggest that IFNα and Tat may be critical targets for anti-AIDS strategies.
AB - HIV type 1 (HIV-1) not only directly kills infected CD4+ T cells but also induces immunosuppression of uninfected T cells. Two immunosuppressive proteins, interferon α (IFNα) and extracellular Tat, mediate this process because specific antibodies against these proteins prevent generation of suppressor cells in HIV-1-infected peripheral blood mononuclear cell cultures. Furthermore, the production of C-C chemokines in response to immune cell activation, initially enhanced by IFNα and Tat, ultimately is inhibited by these proteins in parallel with their induction of immunosuppression. The clinical corollary is the immunosuppression of uninfected T cells and the decline in C-C chemokine release found at advanced stages of HIV-1 infection paralleling rising levels of IFNα and extracellular Tat. We, therefore, suggest that IFNα and Tat may be critical targets for anti-AIDS strategies.
UR - http://www.scopus.com/inward/record.url?scp=13144283615&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=13144283615&partnerID=8YFLogxK
U2 - 10.1073/pnas.95.7.3851
DO - 10.1073/pnas.95.7.3851
M3 - Article
C2 - 9520456
AN - SCOPUS:13144283615
VL - 95
SP - 3851
EP - 3856
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 7
ER -