Interferon α and Tat involvement in the immunosuppression of uninfected T cells and C-C chemokine decline in AIDS

Daniel Zagury, Abderrahim Lachgar, Vida Chams, Lat S. Fall, Jacky Bernard, Jean François Zagury, Bernard Bizzini, Alessandro Gringeri, Elena Santagostino, Jay Rappaport, Michael Feldman, Arsène Burny, Robert C. Gallo

Research output: Contribution to journalArticle

Abstract

HIV type 1 (HIV-1) not only directly kills infected CD4+ T cells but also induces immunosuppression of uninfected T cells. Two immunosuppressive proteins, interferon α (IFNα) and extracellular Tat, mediate this process because specific antibodies against these proteins prevent generation of suppressor cells in HIV-1-infected peripheral blood mononuclear cell cultures. Furthermore, the production of C-C chemokines in response to immune cell activation, initially enhanced by IFNα and Tat, ultimately is inhibited by these proteins in parallel with their induction of immunosuppression. The clinical corollary is the immunosuppression of uninfected T cells and the decline in C-C chemokine release found at advanced stages of HIV-1 infection paralleling rising levels of IFNα and extracellular Tat. We, therefore, suggest that IFNα and Tat may be critical targets for anti-AIDS strategies.

Original languageEnglish
Pages (from-to)3851-3856
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume95
Issue number7
DOIs
Publication statusPublished - Mar 31 1998

ASJC Scopus subject areas

  • Genetics
  • General

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    Zagury, D., Lachgar, A., Chams, V., Fall, L. S., Bernard, J., Zagury, J. F., Bizzini, B., Gringeri, A., Santagostino, E., Rappaport, J., Feldman, M., Burny, A., & Gallo, R. C. (1998). Interferon α and Tat involvement in the immunosuppression of uninfected T cells and C-C chemokine decline in AIDS. Proceedings of the National Academy of Sciences of the United States of America, 95(7), 3851-3856. https://doi.org/10.1073/pnas.95.7.3851