Interferon-α or β potentiate platinum analogous in human glioblastoma cell lines

Sabrina Stanzione, Guido Cimoli, Domizia Debernardis, Andrea Michelotti, PierFranco Conte, Silvio Parodi, Patrizia Russo

Research output: Contribution to journalArticle

Abstract

The effect of interferon-α or β on platinum analogues [cisplatin (CDDP) and carboplatin] cytotoxicity was studied in four glioblastoma cell lines (U373MG, T98G, A172 and U118Mg). All cell lines were strongly resistant to the cytotoxic effect of CDDP or carboplatin. Although both interferons were not cytotoxic in all cell lines, they were able to significantly increase the cell platinum-sensitivity. Specifically interferon-α increased the magnitude of CDDP-induced DNA interstrand crosslinks. Our findings suggest that interferons are able to induce a very strong potentiation of platinum analogues cytotoxicity in drug-resistant human glioma cell lines.

Original languageEnglish
Pages (from-to)131-135
Number of pages5
JournalMutation Research Letters
Volume348
Issue number3
DOIs
Publication statusPublished - 1995

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Keywords

  • DNA damage
  • Glioman
  • Interferons
  • Platinum
  • Potentiation

ASJC Scopus subject areas

  • Genetics
  • Toxicology

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