Interferon-γ and granulocyte-macrophage colony stimulating factor therapy in three patients with pulmonary aspergillosis

A. Bandera, D. Trabattoni, G. Ferrario, M. Cesari, F. Franzetti, M. Clerici, A. Gori

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

An immune response mediated by type 2 cytokines is thought to contribute to the development and unfavorable outcome of aspergillosis. Adjuvant therapy with interferon-γ (IFN-γ) and granulocyte-macrophage colony stimulating factor (GM-CSF) was added to antifungal treatment in three nonneutropenic patients (one HIV-positive and two HIV-negative patients) with culture proven aspergillosis refractory to classical antifungal therapy. Clinical improvement was observed concomitantly with an increase in peripheral blood leukocyte proliferation and type 1 cytokines production. Our findings suggest an association between the improvement in type 1 cytokine production observed during IFN-γ and GM-CSF administration and a better control of Aspergillus infection in patients with progressive disease despite adequate antifungal therapy.

Original languageEnglish
Pages (from-to)368-373
Number of pages6
JournalInfection
Volume36
Issue number4
DOIs
Publication statusPublished - Aug 2008

Fingerprint

Pulmonary Aspergillosis
Granulocyte-Macrophage Colony-Stimulating Factor
Interferons
Aspergillosis
Cytokines
HIV
Aspergillus
Therapeutics
Infection Control
Leukocytes

ASJC Scopus subject areas

  • Microbiology (medical)
  • Immunology

Cite this

Interferon-γ and granulocyte-macrophage colony stimulating factor therapy in three patients with pulmonary aspergillosis. / Bandera, A.; Trabattoni, D.; Ferrario, G.; Cesari, M.; Franzetti, F.; Clerici, M.; Gori, A.

In: Infection, Vol. 36, No. 4, 08.2008, p. 368-373.

Research output: Contribution to journalArticle

Bandera, A. ; Trabattoni, D. ; Ferrario, G. ; Cesari, M. ; Franzetti, F. ; Clerici, M. ; Gori, A. / Interferon-γ and granulocyte-macrophage colony stimulating factor therapy in three patients with pulmonary aspergillosis. In: Infection. 2008 ; Vol. 36, No. 4. pp. 368-373.
@article{9bdc3de747c048378e50c0ad08c976e3,
title = "Interferon-γ and granulocyte-macrophage colony stimulating factor therapy in three patients with pulmonary aspergillosis",
abstract = "An immune response mediated by type 2 cytokines is thought to contribute to the development and unfavorable outcome of aspergillosis. Adjuvant therapy with interferon-γ (IFN-γ) and granulocyte-macrophage colony stimulating factor (GM-CSF) was added to antifungal treatment in three nonneutropenic patients (one HIV-positive and two HIV-negative patients) with culture proven aspergillosis refractory to classical antifungal therapy. Clinical improvement was observed concomitantly with an increase in peripheral blood leukocyte proliferation and type 1 cytokines production. Our findings suggest an association between the improvement in type 1 cytokine production observed during IFN-γ and GM-CSF administration and a better control of Aspergillus infection in patients with progressive disease despite adequate antifungal therapy.",
author = "A. Bandera and D. Trabattoni and G. Ferrario and M. Cesari and F. Franzetti and M. Clerici and A. Gori",
year = "2008",
month = "8",
doi = "10.1007/s15010-008-7378-7",
language = "English",
volume = "36",
pages = "368--373",
journal = "Infection",
issn = "0300-8126",
publisher = "Urban und Vogel GmbH",
number = "4",

}

TY - JOUR

T1 - Interferon-γ and granulocyte-macrophage colony stimulating factor therapy in three patients with pulmonary aspergillosis

AU - Bandera, A.

AU - Trabattoni, D.

AU - Ferrario, G.

AU - Cesari, M.

AU - Franzetti, F.

AU - Clerici, M.

AU - Gori, A.

PY - 2008/8

Y1 - 2008/8

N2 - An immune response mediated by type 2 cytokines is thought to contribute to the development and unfavorable outcome of aspergillosis. Adjuvant therapy with interferon-γ (IFN-γ) and granulocyte-macrophage colony stimulating factor (GM-CSF) was added to antifungal treatment in three nonneutropenic patients (one HIV-positive and two HIV-negative patients) with culture proven aspergillosis refractory to classical antifungal therapy. Clinical improvement was observed concomitantly with an increase in peripheral blood leukocyte proliferation and type 1 cytokines production. Our findings suggest an association between the improvement in type 1 cytokine production observed during IFN-γ and GM-CSF administration and a better control of Aspergillus infection in patients with progressive disease despite adequate antifungal therapy.

AB - An immune response mediated by type 2 cytokines is thought to contribute to the development and unfavorable outcome of aspergillosis. Adjuvant therapy with interferon-γ (IFN-γ) and granulocyte-macrophage colony stimulating factor (GM-CSF) was added to antifungal treatment in three nonneutropenic patients (one HIV-positive and two HIV-negative patients) with culture proven aspergillosis refractory to classical antifungal therapy. Clinical improvement was observed concomitantly with an increase in peripheral blood leukocyte proliferation and type 1 cytokines production. Our findings suggest an association between the improvement in type 1 cytokine production observed during IFN-γ and GM-CSF administration and a better control of Aspergillus infection in patients with progressive disease despite adequate antifungal therapy.

UR - http://www.scopus.com/inward/record.url?scp=50649096799&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=50649096799&partnerID=8YFLogxK

U2 - 10.1007/s15010-008-7378-7

DO - 10.1007/s15010-008-7378-7

M3 - Article

C2 - 18642108

AN - SCOPUS:50649096799

VL - 36

SP - 368

EP - 373

JO - Infection

JF - Infection

SN - 0300-8126

IS - 4

ER -