Interferon-γ levels in serum and bronchoalveolar lavage fluid of mice infected with Bordetella pertussis

Donato Torre, Agostino Pugliese, Filippo Speranza, Giovanni Paolo Fiori, Lorenza Perversi, Piero Marone, Roberto Tambini

Research output: Contribution to journalArticle

Abstract

The adherence of Bordetella pertussis to respiratory cilia and its survival in neutrophils and macrophages is crucial to the pathogenesis of whooping cough. To investigate the role of endogenous interferon (IFN)-γ in acute infection, levels of IFN-γ in bronchoalveolar lavage (BAL) fluid of mice infected intranasally with B. pertussis were determined. Since pertussis toxin is released during infection by B. pertussis either locally or systemically, serum levels of IFN-γ in mice injected intravenously with pertussis toxin were also determined. A persistent and significant increase of IFN-γ levels with concomitant peripheral blood lymphocytosis was observed after 5 and 10 days. The results of this study showed an early but transitory production of endogenous IFN-γ in BAL fluid of mice infected with B. pertussis.

Original languageEnglish
Pages (from-to)762-765
Number of pages4
JournalJournal of Infectious Diseases
Volume167
Issue number3
Publication statusPublished - Mar 1993

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

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    Torre, D., Pugliese, A., Speranza, F., Fiori, G. P., Perversi, L., Marone, P., & Tambini, R. (1993). Interferon-γ levels in serum and bronchoalveolar lavage fluid of mice infected with Bordetella pertussis. Journal of Infectious Diseases, 167(3), 762-765.