Interferon alfa treatment for pregnant women affected by essential thrombocythemia: Case reports and a review

Pasquale Martinelli, Vincenzo Martinelli, Annalisa Agangi, Giuseppe Maria Maruotti, Dario Paladini, Rosanna Ciancia, Bruno Rotoli

Research output: Contribution to journalArticle


In the past essential thrombocythemia was considered a disease of the elderly. At present, the number of young people suffering from this disease is growing, with a slightly higher frequency in females. We investigated the effects of interferon alfa therapy in these patients. We describe 9 pregnancies in 4 women affected by essential thrombocythemia. Four pregnancies were carried out without interferon alfa therapy, and resulted in 2 intrauterine deaths, 1 spontaneous abortion, and 1 neonatal death. Interferon alfa was given during another 5 pregnancies; among them, 2 ended in preterm deliveries with normal infants, and 3 in full-term deliveries. The literature is reviewed. Our cases and published series suggest that fetal outcome is improved by therapy, and that interferon alfa may be the best therapeutic option.

Original languageEnglish
Pages (from-to)2016-2020
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Issue number6
Publication statusPublished - Dec 2004



  • Essential thrombocythemia
  • Fetal outcome
  • Interferon therapy
  • Pregnancy

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynaecology

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