Interferon-alpha treatment of hepatitis D induces tuberculosis exacerbation in an immigrant

Claudia Telesca, Mario Angelico, Paola Piccolo, Lorenzo Nosotti, Aldo Morrone, Chiara Longhi, Marco Carbone, Leonardo Baiocchi

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This report describes the case of a young Romanian patient who developed a severe exacerbation of pulmonary tuberculosis during interferon-alpha treatment for chronic hepatitis D. While this occurrence underscores that clinical guidelines should be applied with caution in immigrants from underdeveloped countries, due to the possible presence of unrecognized or unreported comorbidity, the mechanisms for an interferon-related exacerbation of pulmonary tuberculosis are also examined. We propose that IFN-induced weight loss and anorexia may have played an important role in promoting clinical manifestations of tuberculosis in our patient.

Original languageEnglish
JournalJournal of Infection
Issue number4
Publication statusPublished - Apr 2007


  • Hepatitis D
  • Interferon
  • Tuberculosis

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Microbiology
  • Parasitology
  • Virology
  • Immunology and Allergy
  • Infectious Diseases


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