Background: A functional defect of T regulatory cells (Treg) has been proposed as pathogenic mechanism of allergic reaction. Polysensitization is a common feature of allergic patients. Aim of the study: It was to investigate the possible role of Treg-Th1 cytokines, in the development of new sensitizations in childhood. Methods: Forty monosensitized (MS) children with allergic rhinitis were evaluated and followed-up for 2 years. New sensitizations were investigated. IL-10 and IFN-γ were evaluated in in vitro experiments. Results: Children remaining MS showed significant higher production of both IL-10 and IFN-γ. Conclusion: This preliminary study provided evidence that IL-10 and IFN-γ production could be defective in allergic children prone to develop polysensitization.
|Number of pages||3|
|Journal||Allergy: European Journal of Allergy and Clinical Immunology|
|Publication status||Published - 2010|
- Allergic polysensitization
- T regulatory cells
ASJC Scopus subject areas
- Immunology and Allergy