Interferon-gamma and IL-10 may protect from allergic polysensitization in children: Preliminary evidence

I. Prigione, F. Morandi, M. A. Tosca, M. Silvestri, V. Pistoia, G. Ciprandi, G. A. Rossi

Research output: Contribution to journalArticlepeer-review

Abstract

Background: A functional defect of T regulatory cells (Treg) has been proposed as pathogenic mechanism of allergic reaction. Polysensitization is a common feature of allergic patients. Aim of the study: It was to investigate the possible role of Treg-Th1 cytokines, in the development of new sensitizations in childhood. Methods: Forty monosensitized (MS) children with allergic rhinitis were evaluated and followed-up for 2 years. New sensitizations were investigated. IL-10 and IFN-γ were evaluated in in vitro experiments. Results: Children remaining MS showed significant higher production of both IL-10 and IFN-γ. Conclusion: This preliminary study provided evidence that IL-10 and IFN-γ production could be defective in allergic children prone to develop polysensitization.

Original languageEnglish
Pages (from-to)740-742
Number of pages3
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume65
Issue number6
DOIs
Publication statusPublished - 2010

Keywords

  • Allergic polysensitization
  • Cytokines
  • T regulatory cells

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Medicine(all)

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