Interferon induced with helicase C domain 1 (IFIH1): Trends on helicase domain and type 1 diabetes onset

Ronald Moura, Jacqueline Araujo, Rafael Guimarães, Sergio Crovella, Lucas Brandão

Research output: Contribution to journalArticlepeer-review

Abstract

The Interferon-induced with helicase C domain 1 (IFIH1) gene has been hypothesized as involved in the viral etiology of type 1 diabetes (T1D) and other autoimmune disorders, since it is implicated in viral recognition. In our study we analyzed IFIH1 rs6432714 and rs10930046 SNPs in T1D patients stratified for the presence of celiac disease and autoimmune thyroid disease. No association with susceptibility to develop the diseases was found. The rs6432714, a tag-SNP that represents part of helicase domain of IF1H1 protein showed a trend of association only with T1D development (P. >0.025 after Bonferroni adjustment) in log-additive model (OR = 1.45, P = 0.0365, power = 0.99), indicating that helicase domain of IFIH1 protein could be associated with the susceptibility to T1D.

Original languageEnglish
Pages (from-to)66-68
Number of pages3
JournalGene
Volume516
Issue number1
DOIs
Publication statusPublished - Mar 1 2013

Keywords

  • Autoimmune diseases
  • Enterovirus response
  • Genetic susceptibility
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Genetics

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