Interferon inhibition of neoplastic phenotype in cell lines harbouring human papillomavirus sequences

F. De Marco, A. Di Lonardo, A. Venuti, M. L. Marcante

Research output: Contribution to journalArticlepeer-review

Abstract

The transformed phenotype is markedly affected by Interferon (IFN) long term treatment in HeLa and Siha cell lines. Two months of continuous exposure to 100 and 1000 International Units (IU)/ml of human recombinant αIFN causes a drastic reduction of anchorage independent growth in soft-agar. No effect on in vitro growing potential was observed at the same concentrations. This antiproliferative effect in soft-agar was more pronounced in Siha than in Hela cells and was concentration and time dependent. The Human Papillomavirus (HPV) sequences inserted in the cell genome apparently were unaffected as their RNA expression, indicating that IFN may modulate aspects of transformed phenotype regulated by genes other than HPV sequences.

Original languageEnglish
Pages (from-to)65-70
Number of pages6
JournalJournal of Biological Regulators and Homeostatic Agents
Volume5
Issue number2
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Physiology (medical)
  • Medicine (miscellaneous)
  • Physiology
  • Agricultural and Biological Sciences(all)

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