Interferon lambda 3 rs12979860 polymorphism in patients with haemophilia and HCV infection: A predictor of spontaneous viral clearance and sustained virological response

Maria Elisa Mancuso, Silvia Linari, Alessio Aghemo, Dario Bartolozzi, Elena Santagostino, Maria Grazia Rumi, Elisa Fognani, Maria Rosaria Fasulo, Laura Gragnani, Raffaele Bruno, Massimo Morfini, Anna Linda Zignego, Massimo Colombo

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Chronic hepatitis C is the main cause of morbidity and mortality in adult haemophilic patients who received non-virally inactivated plasma- derived clotting factor concentrates. Overall, spontaneous viral clearance rate is 10-25% and the only approach that can halt disease progression is hepatitis C virus (HCV) eradication by means of antiviral therapy. In non-haemophilic patients a single nucleotide polymorphism located upstream the gene of interferon lambda 3 (IFN3) has been associated with both spontaneous viral clearance and sustained virological response after antiviral treatment. The aim of this study was to assess whether the rs12979860 polymorphism was a predictor of spontaneous viral clearance and of sustained virological response after antiviral therapy in a large cohort of haemophilic patients with HCV infection. The rs12979860 polymorphism, defined as CC genotype or T allele, was tested in a cohort of 342 haemophilic patients and evaluated as predictor of spontaneous clearance or response to antiviral therapy. By multivariate regression analysis the IFN3 CC genotype was an independent predictor of spontaneous viral clearance (odds ratio: 3.7, 95% confidence interval: 2.0-6.8). Sustained virological response rates were doubled in patients with the CC genotype than in those with the T allele (78% vs 44%; p

Original languageEnglish
Pages (from-to)1067-1076
Number of pages10
JournalThrombosis and Haemostasis
Volume111
Issue number6
DOIs
Publication statusPublished - Feb 13 2014

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Factor XI Deficiency
Virus Diseases
Hepacivirus
Interferons
Antiviral Agents
Genotype
Alleles
Blood Coagulation Factors
Chronic Hepatitis C
Therapeutics
Single Nucleotide Polymorphism
Disease Progression
Multivariate Analysis
Odds Ratio
Regression Analysis
Confidence Intervals
Morbidity
Mortality
Genes

Keywords

  • Antiviral therapy
  • Chronic hepatitis C
  • Haemophilia
  • Interferon lambda 3
  • Spontaneous clearance

ASJC Scopus subject areas

  • Hematology
  • Medicine(all)

Cite this

Interferon lambda 3 rs12979860 polymorphism in patients with haemophilia and HCV infection : A predictor of spontaneous viral clearance and sustained virological response. / Mancuso, Maria Elisa; Linari, Silvia; Aghemo, Alessio; Bartolozzi, Dario; Santagostino, Elena; Rumi, Maria Grazia; Fognani, Elisa; Fasulo, Maria Rosaria; Gragnani, Laura; Bruno, Raffaele; Morfini, Massimo; Zignego, Anna Linda; Colombo, Massimo.

In: Thrombosis and Haemostasis, Vol. 111, No. 6, 13.02.2014, p. 1067-1076.

Research output: Contribution to journalArticle

Mancuso, Maria Elisa ; Linari, Silvia ; Aghemo, Alessio ; Bartolozzi, Dario ; Santagostino, Elena ; Rumi, Maria Grazia ; Fognani, Elisa ; Fasulo, Maria Rosaria ; Gragnani, Laura ; Bruno, Raffaele ; Morfini, Massimo ; Zignego, Anna Linda ; Colombo, Massimo. / Interferon lambda 3 rs12979860 polymorphism in patients with haemophilia and HCV infection : A predictor of spontaneous viral clearance and sustained virological response. In: Thrombosis and Haemostasis. 2014 ; Vol. 111, No. 6. pp. 1067-1076.
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