The effect of long-term administration of interferon in New Zealand Black and New Zealand Black/New Zealand White F 1 hybrid mice was studied. Treatment with moderate doses of interferon (10 4 units, 5 times weekly for 8 weeks) did not depress murine leukemia virus gp69/71 levels in serum and spleen, nor p30 levels in the spleen. Interferon given at 10 5.1 units (3 times weekly for 37 weeks) caused an increased incidence of anti-erythrocyte antibodies in New Zealand Black mice. Finally, the hybrid mice given interferon at 10 6.0 units (3 times weekly for 33 weeks) had increased renal immune complex deposits and increased incidences of proteinuria and anemia.
|Number of pages||6|
|Journal||Infection and Immunity|
|Publication status||Published - 1978|
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