Interferon treatment of NZB mice: Accelerated progression of autoimmune disease

H. Heremans, A. Billiau, A. Colombatti, J. Hilgers, P. de Somer

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of long-term administration of interferon in New Zealand Black and New Zealand Black/New Zealand White F 1 hybrid mice was studied. Treatment with moderate doses of interferon (10 4 units, 5 times weekly for 8 weeks) did not depress murine leukemia virus gp69/71 levels in serum and spleen, nor p30 levels in the spleen. Interferon given at 10 5.1 units (3 times weekly for 37 weeks) caused an increased incidence of anti-erythrocyte antibodies in New Zealand Black mice. Finally, the hybrid mice given interferon at 10 6.0 units (3 times weekly for 33 weeks) had increased renal immune complex deposits and increased incidences of proteinuria and anemia.

Original languageEnglish
Pages (from-to)925-930
Number of pages6
JournalInfection and Immunity
Volume21
Issue number3
Publication statusPublished - 1978

ASJC Scopus subject areas

  • Immunology

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