Interferons up-regulate with different potency HLA class I antigen expression in M14 human melanoma cell line. Possible interaction with glucocorticoid hormones

Lorella Lanza, Lorenza Peirano, Ornella Bosco, Paola Contini, Gilberto Filaci, Maurizio Setti, Francesco Puppo, Francesco Indiveri, Marco Scudeletti

Research output: Contribution to journalArticlepeer-review

Abstract

The relative potency of interferon α (IFNα), interferon β (IFNβ), and interferon γ (IFNγ) in inducing the expression of HLA class I antigens, as well as their capacity to counteract the inhibition induced by glucocorticoid hormones on HLA class I antigen expression, were analysed in the human melanoma cell line M14, both at membrane and at mRNA level. The data obtained indicate that (a) IFN enhance with different potency (IFNγ>IFNβ>IFNα) the expression of HLA class I antigens in M14 cells, (b) prednisone inhibits HLA class I antigen expresion, (c) glucocorticoid hormones, when associated with IFNα or IFNγ, inhibit the HLA class I enhancement induced by IFN alone, and ffinally, (c) the association between 1 μM prednisone or 1 μM deflazacort and IFNβ seems to potentiate the enhancing capacity of IFN on the expression of HLA class I molecules at the mRNA level. These findings, if confirmed, might indicate that IFN and glucocorticoid hormones are not mutually exclusive in the management of human melanoma.

Original languageEnglish
Pages (from-to)23-28
Number of pages6
JournalCancer Immunology, Immunotherapy
Volume41
Issue number1
DOIs
Publication statusPublished - Jan 1995

Keywords

  • Deflazacort
  • HLA classI
  • Human melanoma
  • IFNα
  • IFNβ
  • IFNγ
  • Prednisone

ASJC Scopus subject areas

  • Oncology
  • Immunology
  • Cancer Research

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