Interictal abnormalities of gamma band activity in visual evoked responses in migraine: An indication of thalamocortical dysrhythmia?

G. Coppola, A. Ambrosini, L. Di Clemente, D. Magis, A. Fumal, P. Gérard, F. Pierelli, J. Schoenen

Research output: Contribution to journalArticlepeer-review

Abstract

Between attacks, migraineurs lack habituation in standard visual evoked potentials (VEPs). Visual stimuli also evoke high-frequency oscillations in the gamma band range (GBOs, 20-35 Hz) assumed to be generated both at subcortical (early GBOs) and cortical levels (late GBOs). The consecutive peaks of GBOs were analysed regarding amplitude and habituation in six successive blocks of 100 averaged pattern reversal (PR)-VEPs in healthy volunteers and interictally in migraine with (MA) or without aura patients. Amplitude of the two early GBO components in the first PR-VEP block was significantly increased in MA patients. There was a significant habituation deficit of the late GBO peaks in migraineurs. The increased amplitude of early GBOs could be related to the increased interictal visual discomfort reported by patients. We hypothesize that the hypofunctioning serotonergic pathways may cause, in line with the thalamocortical dysrhythmia theory, a functional disconnection of the thalamus leading to decreased intracortical lateral inhibition, which can induce dishabituation.

Original languageEnglish
Pages (from-to)1360-1367
Number of pages8
JournalCephalalgia
Volume27
Issue number12
DOIs
Publication statusPublished - Dec 2007

Keywords

  • Gamma band
  • Habituation
  • Migraine
  • Thalamocortical dysrhythmia
  • Visual evoked potentials

ASJC Scopus subject areas

  • Clinical Neurology

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