TY - JOUR
T1 - Interictal abnormalities of gamma band activity in visual evoked responses in migraine
T2 - An indication of thalamocortical dysrhythmia?
AU - Coppola, G.
AU - Ambrosini, A.
AU - Di Clemente, L.
AU - Magis, D.
AU - Fumal, A.
AU - Gérard, P.
AU - Pierelli, F.
AU - Schoenen, J.
PY - 2007/12
Y1 - 2007/12
N2 - Between attacks, migraineurs lack habituation in standard visual evoked potentials (VEPs). Visual stimuli also evoke high-frequency oscillations in the gamma band range (GBOs, 20-35 Hz) assumed to be generated both at subcortical (early GBOs) and cortical levels (late GBOs). The consecutive peaks of GBOs were analysed regarding amplitude and habituation in six successive blocks of 100 averaged pattern reversal (PR)-VEPs in healthy volunteers and interictally in migraine with (MA) or without aura patients. Amplitude of the two early GBO components in the first PR-VEP block was significantly increased in MA patients. There was a significant habituation deficit of the late GBO peaks in migraineurs. The increased amplitude of early GBOs could be related to the increased interictal visual discomfort reported by patients. We hypothesize that the hypofunctioning serotonergic pathways may cause, in line with the thalamocortical dysrhythmia theory, a functional disconnection of the thalamus leading to decreased intracortical lateral inhibition, which can induce dishabituation.
AB - Between attacks, migraineurs lack habituation in standard visual evoked potentials (VEPs). Visual stimuli also evoke high-frequency oscillations in the gamma band range (GBOs, 20-35 Hz) assumed to be generated both at subcortical (early GBOs) and cortical levels (late GBOs). The consecutive peaks of GBOs were analysed regarding amplitude and habituation in six successive blocks of 100 averaged pattern reversal (PR)-VEPs in healthy volunteers and interictally in migraine with (MA) or without aura patients. Amplitude of the two early GBO components in the first PR-VEP block was significantly increased in MA patients. There was a significant habituation deficit of the late GBO peaks in migraineurs. The increased amplitude of early GBOs could be related to the increased interictal visual discomfort reported by patients. We hypothesize that the hypofunctioning serotonergic pathways may cause, in line with the thalamocortical dysrhythmia theory, a functional disconnection of the thalamus leading to decreased intracortical lateral inhibition, which can induce dishabituation.
KW - Gamma band
KW - Habituation
KW - Migraine
KW - Thalamocortical dysrhythmia
KW - Visual evoked potentials
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U2 - 10.1111/j.1468-2982.2007.01466.x
DO - 10.1111/j.1468-2982.2007.01466.x
M3 - Article
C2 - 17986271
AN - SCOPUS:36348940426
VL - 27
SP - 1360
EP - 1367
JO - Cephalalgia
JF - Cephalalgia
SN - 0333-1024
IS - 12
ER -