Interictal habituation deficit of the nociceptive blink reflex: An endophenotypic marker for presymptomatic migraine?

L. Di Clemente, G. Coppola, D. Magis, A. Fumal, V. De Pasqua, V. Di Piero, J. Schoenen

Research output: Contribution to journalArticle

Abstract

Habituation of the nociception-specific blink reflex (nBR) is reduced interictally in migraine patients. This could be related to the habituation deficit of evoked cortical responses, a reproducible abnormality in migraine which has a familial character, or to central trigeminal sensitization due to repeated attacks. We compared nBR habituation in healthy volunteers devoid of personal or family history of migraine (HV), in migraine without aura patients (MO) and in healthy volunteers with a family history of migraine in first degree relatives (HV-F). We elicited the nBR by stimulating the right supraorbital region with a custom-built electrode in 16 MO between attacks, 15 HV and 14 HV-F. Habituation was measured as the percentage area-under-the-curve decrease in 10 consecutive blocks of five averaged rectified responses. nBR habituation was clearly reduced in MO and HV-F compared to HV. Percentage area under the curve decreased between the 1st and the 10th block by 55.01% in HV, 25.71% in MO (P = 0.001) and 26.73% in HV-F (P = 0.043). HV-F had the most pronounced abnormality with potentiation instead of habituation in the second block. We found a positive intraindividual correlation between attack frequency and habituation in MO (r = 0.621; P = 0.010). Migraine patients have interictally a deficient habituation of the nBR which is inversely related to attack frequency, suggesting that it is not due to trigeminal sensitization. Surprisingly, the most pronounced habituation deficit is found in asymptomatic individuals with a family history of migraine. Deficient nBR habituation could thus be a trait marker for the genetic predisposition to migraine.

Original languageEnglish
Pages (from-to)765-770
Number of pages6
JournalBrain
Volume130
Issue number3
DOIs
Publication statusPublished - Mar 2007

Fingerprint

Blinking
Nociception
Migraine Disorders
Area Under Curve
Healthy Volunteers
Central Nervous System Sensitization
Migraine without Aura
Genetic Predisposition to Disease
Electrodes

Keywords

  • Brain circuits
  • Migraine
  • Sensory processing

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Di Clemente, L., Coppola, G., Magis, D., Fumal, A., De Pasqua, V., Di Piero, V., & Schoenen, J. (2007). Interictal habituation deficit of the nociceptive blink reflex: An endophenotypic marker for presymptomatic migraine? Brain, 130(3), 765-770. https://doi.org/10.1093/brain/awl351

Interictal habituation deficit of the nociceptive blink reflex : An endophenotypic marker for presymptomatic migraine? / Di Clemente, L.; Coppola, G.; Magis, D.; Fumal, A.; De Pasqua, V.; Di Piero, V.; Schoenen, J.

In: Brain, Vol. 130, No. 3, 03.2007, p. 765-770.

Research output: Contribution to journalArticle

Di Clemente, L, Coppola, G, Magis, D, Fumal, A, De Pasqua, V, Di Piero, V & Schoenen, J 2007, 'Interictal habituation deficit of the nociceptive blink reflex: An endophenotypic marker for presymptomatic migraine?', Brain, vol. 130, no. 3, pp. 765-770. https://doi.org/10.1093/brain/awl351
Di Clemente, L. ; Coppola, G. ; Magis, D. ; Fumal, A. ; De Pasqua, V. ; Di Piero, V. ; Schoenen, J. / Interictal habituation deficit of the nociceptive blink reflex : An endophenotypic marker for presymptomatic migraine?. In: Brain. 2007 ; Vol. 130, No. 3. pp. 765-770.
@article{cb9c768af03244ce9c52a5a4d4043b04,
title = "Interictal habituation deficit of the nociceptive blink reflex: An endophenotypic marker for presymptomatic migraine?",
abstract = "Habituation of the nociception-specific blink reflex (nBR) is reduced interictally in migraine patients. This could be related to the habituation deficit of evoked cortical responses, a reproducible abnormality in migraine which has a familial character, or to central trigeminal sensitization due to repeated attacks. We compared nBR habituation in healthy volunteers devoid of personal or family history of migraine (HV), in migraine without aura patients (MO) and in healthy volunteers with a family history of migraine in first degree relatives (HV-F). We elicited the nBR by stimulating the right supraorbital region with a custom-built electrode in 16 MO between attacks, 15 HV and 14 HV-F. Habituation was measured as the percentage area-under-the-curve decrease in 10 consecutive blocks of five averaged rectified responses. nBR habituation was clearly reduced in MO and HV-F compared to HV. Percentage area under the curve decreased between the 1st and the 10th block by 55.01{\%} in HV, 25.71{\%} in MO (P = 0.001) and 26.73{\%} in HV-F (P = 0.043). HV-F had the most pronounced abnormality with potentiation instead of habituation in the second block. We found a positive intraindividual correlation between attack frequency and habituation in MO (r = 0.621; P = 0.010). Migraine patients have interictally a deficient habituation of the nBR which is inversely related to attack frequency, suggesting that it is not due to trigeminal sensitization. Surprisingly, the most pronounced habituation deficit is found in asymptomatic individuals with a family history of migraine. Deficient nBR habituation could thus be a trait marker for the genetic predisposition to migraine.",
keywords = "Brain circuits, Migraine, Sensory processing",
author = "{Di Clemente}, L. and G. Coppola and D. Magis and A. Fumal and {De Pasqua}, V. and {Di Piero}, V. and J. Schoenen",
year = "2007",
month = "3",
doi = "10.1093/brain/awl351",
language = "English",
volume = "130",
pages = "765--770",
journal = "Brain",
issn = "0006-8950",
publisher = "Oxford University Press",
number = "3",

}

TY - JOUR

T1 - Interictal habituation deficit of the nociceptive blink reflex

T2 - An endophenotypic marker for presymptomatic migraine?

AU - Di Clemente, L.

AU - Coppola, G.

AU - Magis, D.

AU - Fumal, A.

AU - De Pasqua, V.

AU - Di Piero, V.

AU - Schoenen, J.

PY - 2007/3

Y1 - 2007/3

N2 - Habituation of the nociception-specific blink reflex (nBR) is reduced interictally in migraine patients. This could be related to the habituation deficit of evoked cortical responses, a reproducible abnormality in migraine which has a familial character, or to central trigeminal sensitization due to repeated attacks. We compared nBR habituation in healthy volunteers devoid of personal or family history of migraine (HV), in migraine without aura patients (MO) and in healthy volunteers with a family history of migraine in first degree relatives (HV-F). We elicited the nBR by stimulating the right supraorbital region with a custom-built electrode in 16 MO between attacks, 15 HV and 14 HV-F. Habituation was measured as the percentage area-under-the-curve decrease in 10 consecutive blocks of five averaged rectified responses. nBR habituation was clearly reduced in MO and HV-F compared to HV. Percentage area under the curve decreased between the 1st and the 10th block by 55.01% in HV, 25.71% in MO (P = 0.001) and 26.73% in HV-F (P = 0.043). HV-F had the most pronounced abnormality with potentiation instead of habituation in the second block. We found a positive intraindividual correlation between attack frequency and habituation in MO (r = 0.621; P = 0.010). Migraine patients have interictally a deficient habituation of the nBR which is inversely related to attack frequency, suggesting that it is not due to trigeminal sensitization. Surprisingly, the most pronounced habituation deficit is found in asymptomatic individuals with a family history of migraine. Deficient nBR habituation could thus be a trait marker for the genetic predisposition to migraine.

AB - Habituation of the nociception-specific blink reflex (nBR) is reduced interictally in migraine patients. This could be related to the habituation deficit of evoked cortical responses, a reproducible abnormality in migraine which has a familial character, or to central trigeminal sensitization due to repeated attacks. We compared nBR habituation in healthy volunteers devoid of personal or family history of migraine (HV), in migraine without aura patients (MO) and in healthy volunteers with a family history of migraine in first degree relatives (HV-F). We elicited the nBR by stimulating the right supraorbital region with a custom-built electrode in 16 MO between attacks, 15 HV and 14 HV-F. Habituation was measured as the percentage area-under-the-curve decrease in 10 consecutive blocks of five averaged rectified responses. nBR habituation was clearly reduced in MO and HV-F compared to HV. Percentage area under the curve decreased between the 1st and the 10th block by 55.01% in HV, 25.71% in MO (P = 0.001) and 26.73% in HV-F (P = 0.043). HV-F had the most pronounced abnormality with potentiation instead of habituation in the second block. We found a positive intraindividual correlation between attack frequency and habituation in MO (r = 0.621; P = 0.010). Migraine patients have interictally a deficient habituation of the nBR which is inversely related to attack frequency, suggesting that it is not due to trigeminal sensitization. Surprisingly, the most pronounced habituation deficit is found in asymptomatic individuals with a family history of migraine. Deficient nBR habituation could thus be a trait marker for the genetic predisposition to migraine.

KW - Brain circuits

KW - Migraine

KW - Sensory processing

UR - http://www.scopus.com/inward/record.url?scp=33947097466&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33947097466&partnerID=8YFLogxK

U2 - 10.1093/brain/awl351

DO - 10.1093/brain/awl351

M3 - Article

C2 - 17251239

AN - SCOPUS:33947097466

VL - 130

SP - 765

EP - 770

JO - Brain

JF - Brain

SN - 0006-8950

IS - 3

ER -