Interim fluorine-18 fluorodeoxyglucose positron emission tomography forearly metabolic assessment of therapeutic response to chemotherapy for metastatic transitional cell carcinoma

Patrizia Giannatempo; Alessandra Alessi; Rosalba Miceli; Daniele Raggi; Elena Farè; Nicola Nicolai; Gianluca Serafini; Barbara Padovano; Luigi Piva; Davide Biasoni; Tullio Torelli; Mario Catanzaro; Silvia Stagni; Massimo Maffezzini; Luigi Mariani; Alessandro M. Gianni; Guru Sonpavde; Roberto Salvioni; Andrea Necchi; Flavio Crippa

doi:10.1016/j.clgc.2014.03.007

Interim fluorine-18 fluorodeoxyglucose positron emission tomography forearly metabolic assessment of therapeutic response to chemotherapy for metastatic transitional cell carcinoma

Patrizia Giannatempo, Alessandra Alessi, Rosalba Miceli, Daniele Raggi, Elena Farè, Nicola Nicolai, Gianluca Serafini, Barbara Padovano, Luigi Piva, Davide Biasoni, Tullio Torelli, Mario Catanzaro, Silvia Stagni, Massimo Maffezzini, Luigi Mariani, Alessandro M. Gianni, Guru Sonpavde, Roberto Salvioni, Andrea Necchi, Flavio Crippa

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article

Abstract

Fluorine-18 fluorodeoxyglucose positron emission tomography is increasingly used by many centers for staging and response assessment of metastatic transitional cell carcinoma. We prospectively evaluated 31 patients undergoing metabolic restaging after only 2 cycles of first-line chemotherapy (PET2). Early metabolic response was associated with patient outcome. The aim was to provide a proof of principle for a risk-adapted approach based on PET2 that may guide new trial design for early-recognized unresponsive patients.

Original language	English
Pages (from-to)	433-439
Number of pages	7
Journal	Clinical Genitourinary Cancer
Volume	12
Issue number	6
DOIs	https://doi.org/10.1016/j.clgc.2014.03.007
Publication status	Published - 2014

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Keywords

Imaging biomarkers
Metabolic response
Positron emission tomography
Transitional cell carcinoma
Urothelial cancer

ASJC Scopus subject areas

Oncology
Urology
Medicine(all)

Cite this

Giannatempo, P., Alessi, A., Miceli, R., Raggi, D., Farè, E., Nicolai, N., Serafini, G., Padovano, B., Piva, L., Biasoni, D., Torelli, T., Catanzaro, M., Stagni, S., Maffezzini, M., Mariani, L., Gianni, A. M., Sonpavde, G., Salvioni, R., Necchi, A., & Crippa, F. (2014). Interim fluorine-18 fluorodeoxyglucose positron emission tomography forearly metabolic assessment of therapeutic response to chemotherapy for metastatic transitional cell carcinoma. Clinical Genitourinary Cancer, 12(6), 433-439. https://doi.org/10.1016/j.clgc.2014.03.007

Interim fluorine-18 fluorodeoxyglucose positron emission tomography forearly metabolic assessment of therapeutic response to chemotherapy for metastatic transitional cell carcinoma. / Giannatempo, Patrizia ; Alessi, Alessandra ; Miceli, Rosalba; Raggi, Daniele; Farè, Elena; Nicolai, Nicola; Serafini, Gianluca; Padovano, Barbara ; Piva, Luigi ; Biasoni, Davide ; Torelli, Tullio ; Catanzaro, Mario ; Stagni, Silvia; Maffezzini, Massimo; Mariani, Luigi ; Gianni, Alessandro M.; Sonpavde, Guru; Salvioni, Roberto ; Necchi, Andrea; Crippa, Flavio.

In: Clinical Genitourinary Cancer, Vol. 12, No. 6, 2014, p. 433-439.

Research output: Contribution to journal › Article

Giannatempo, P , Alessi, A , Miceli, R, Raggi, D, Farè, E, Nicolai, N, Serafini, G, Padovano, B , Piva, L , Biasoni, D , Torelli, T , Catanzaro, M , Stagni, S, Maffezzini, M, Mariani, L , Gianni, AM, Sonpavde, G, Salvioni, R , Necchi, A & Crippa, F 2014, 'Interim fluorine-18 fluorodeoxyglucose positron emission tomography forearly metabolic assessment of therapeutic response to chemotherapy for metastatic transitional cell carcinoma', Clinical Genitourinary Cancer, vol. 12, no. 6, pp. 433-439. https://doi.org/10.1016/j.clgc.2014.03.007

Giannatempo, Patrizia ; Alessi, Alessandra ; Miceli, Rosalba ; Raggi, Daniele ; Farè, Elena ; Nicolai, Nicola ; Serafini, Gianluca ; Padovano, Barbara ; Piva, Luigi ; Biasoni, Davide ; Torelli, Tullio ; Catanzaro, Mario ; Stagni, Silvia ; Maffezzini, Massimo ; Mariani, Luigi ; Gianni, Alessandro M. ; Sonpavde, Guru ; Salvioni, Roberto ; Necchi, Andrea ; Crippa, Flavio. / Interim fluorine-18 fluorodeoxyglucose positron emission tomography forearly metabolic assessment of therapeutic response to chemotherapy for metastatic transitional cell carcinoma. In: Clinical Genitourinary Cancer. 2014 ; Vol. 12, No. 6. pp. 433-439.

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AU - Farè, Elena

AU - Nicolai, Nicola

AU - Serafini, Gianluca

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AU - Biasoni, Davide

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Access to Document

10.1016/j.clgc.2014.03.007