TY - JOUR
T1 - Interim fluorine-18 fluorodeoxyglucose positron emission tomography forearly metabolic assessment of therapeutic response to chemotherapy for metastatic transitional cell carcinoma
AU - Giannatempo, Patrizia
AU - Alessi, Alessandra
AU - Miceli, Rosalba
AU - Raggi, Daniele
AU - Farè, Elena
AU - Nicolai, Nicola
AU - Serafini, Gianluca
AU - Padovano, Barbara
AU - Piva, Luigi
AU - Biasoni, Davide
AU - Torelli, Tullio
AU - Catanzaro, Mario
AU - Stagni, Silvia
AU - Maffezzini, Massimo
AU - Mariani, Luigi
AU - Gianni, Alessandro M.
AU - Sonpavde, Guru
AU - Salvioni, Roberto
AU - Necchi, Andrea
AU - Crippa, Flavio
PY - 2014
Y1 - 2014
N2 - Fluorine-18 fluorodeoxyglucose positron emission tomography is increasingly used by many centers for staging and response assessment of metastatic transitional cell carcinoma. We prospectively evaluated 31 patients undergoing metabolic restaging after only 2 cycles of first-line chemotherapy (PET2). Early metabolic response was associated with patient outcome. The aim was to provide a proof of principle for a risk-adapted approach based on PET2 that may guide new trial design for early-recognized unresponsive patients.
AB - Fluorine-18 fluorodeoxyglucose positron emission tomography is increasingly used by many centers for staging and response assessment of metastatic transitional cell carcinoma. We prospectively evaluated 31 patients undergoing metabolic restaging after only 2 cycles of first-line chemotherapy (PET2). Early metabolic response was associated with patient outcome. The aim was to provide a proof of principle for a risk-adapted approach based on PET2 that may guide new trial design for early-recognized unresponsive patients.
KW - Imaging biomarkers
KW - Metabolic response
KW - Positron emission tomography
KW - Transitional cell carcinoma
KW - Urothelial cancer
UR - http://www.scopus.com/inward/record.url?scp=84922702191&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84922702191&partnerID=8YFLogxK
U2 - 10.1016/j.clgc.2014.03.007
DO - 10.1016/j.clgc.2014.03.007
M3 - Article
C2 - 24787972
AN - SCOPUS:84922702191
VL - 12
SP - 433
EP - 439
JO - Clinical Genitourinary Cancer
JF - Clinical Genitourinary Cancer
SN - 1558-7673
IS - 6
ER -