Interindividual variability of drug transporters: Impact on opioid treatment in chronic renal failure

Guglielmina Nadia Ranzani, Simona De Gregori, Manuela De Gregori, Mario Regazzi, Stefano Govoni

Research output: Contribution to journalArticlepeer-review

Abstract

Some transmembrane transporters influence the absorption, the tissue distribution and the elimination of opioids, and their genetic variants may be an important factor in therapeutic efficacy and toxicity. Uptake and efflux transporters may facilitate or limit access of opioids to blood-brain barrier (BBB), modulating pain relief. As renal function is crucial in the metabolism and pharmacokinetic profile of any drug, renal failure and end-stage renal disease may alter drug disposition by affecting protein and tissue binding, and reducing systemic clearance of drugs.

Original languageEnglish
Pages (from-to)21-28
Number of pages8
JournalEuropean Journal of Pain Supplements
Volume3
Issue number2
DOIs
Publication statusPublished - Nov 2009

Keywords

  • Chronic renal failure
  • Dialysis
  • Opioids
  • Polymorphism
  • Transporters

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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