Interlaboratory reproducibility of atypical squamous cells of undetermined significance report: A national survey

Massimo Confortini, F. Carozzi, P. Dalla Palma, B. Ghiringhello, F. Parisio, S. Prandi, G. Ronco, S. Ciatto, G. Montanari

Research output: Contribution to journalArticle

Abstract

The study was aimed at assessing interlaboratory reproducibility in the reporting of cervical smears in the atypical squamous cells of undetermined significance (ASCUS) category. A set of 50 selected slides circulated among 89 laboratories, currently involved in population-based screening programmes for cervical cancer, which provided a diagnostic report according to four main reporting categories based on the 1991 Bethesda system. Interlaboratory agreement was determined according to kappa (K) statistics: overall and weighted K values were determined for each laboratory and for single reporting categories. The results showed a very low reproducibility for the ASCUS category. This finding supports the Bethesda system 1991 recommendation to limit the use of this reporting category and suggests that the clinical response to ASCUS reports should be decided locally, based on the observed positive predictive value for cervical intraepithelial neoplasia 2 or more severe lesions.

Original languageEnglish
Pages (from-to)263-268
Number of pages6
JournalCytopathology
Volume14
Issue number5
DOIs
Publication statusPublished - Oct 2003

Keywords

  • Atypical squamous cells of undetermined significance
  • Cervical cancer screening
  • Cervical smear
  • Reproducibility

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology

Fingerprint Dive into the research topics of 'Interlaboratory reproducibility of atypical squamous cells of undetermined significance report: A national survey'. Together they form a unique fingerprint.

  • Cite this

    Confortini, M., Carozzi, F., Dalla Palma, P., Ghiringhello, B., Parisio, F., Prandi, S., Ronco, G., Ciatto, S., & Montanari, G. (2003). Interlaboratory reproducibility of atypical squamous cells of undetermined significance report: A national survey. Cytopathology, 14(5), 263-268. https://doi.org/10.1046/j.1365-2303.2003.00061.x