Interlamellar lipid differences between normal and psoriatic stratum corneum

S. Motta, S. Sesana, M. Monti, A. Giuliani, R. Caputo

Research output: Contribution to journalArticlepeer-review


Intercellular lipids of the stratum corneum are involved in permeability barrier integrity and function. In psoriasis, desquamation aud permeability barrier homeostasis are modified; these observations are consistent with an alteration in stratum corneum lipid production. Therefore, in the present study, we determined and compared the total content of the three main intercellular lipids in psoriatic scales and normal human stratum corneum. Our results showed that the relative free fatty acid content decreased remarkably (46%) in psoriatic scales, compared with normal human stratum corneum. This decrease may reflect a general state of emergency of keratinocytes, in which free fatty acids can be employed.

Original languageEnglish
Pages (from-to)131-132
Number of pages2
JournalActa Dermato-Venereologica, Supplement
Issue number186
Publication statusPublished - 1994


  • abnormal desquamation
  • linoleic acid
  • permeability barrier

ASJC Scopus subject areas

  • Dermatology

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