Interleukin-1β and interleukin-6 in arthritis animal models: Roles in the early phase of transition from acute to chronic inflammation and relevance for human rheumatoid arthritis

Gianfranco Ferraccioli, Luisa Bracci-Laudiero, Stefano Alivernini, Elisa Gremese, Barbara Tolusso, Fabrizio de Benedetti

Research output: Contribution to journalArticle

Abstract

Tumor necrosis factor-α (TNF-α) is the major target of the therapeutic approach in rheumatoid arthritis. A key issue in the approach to chronic arthritis is the understanding of the crucial molecules driving the transition from the acute phase to the chronic irreversible phase of the disease. In this review we analyzed five experimental arthritis animal models (antigen-induced arthritis, adjuvant-induced arthritis, streptococcal cell wall arthritis, collagen-induced arthritis and SKG) considered as possible scenarios to facilitate interpretation of the biology of human rheumatoid arthritis. The SKG model is strictly dependent on interleukin (IL)-6. In the other models, IL-1β and IL-6, more than TNF-α, appear to be relevant in driving the transition, which suggests that these should be the targets of an early intervention to stop the course toward the chronic form of the disease.

Original languageEnglish
Pages (from-to)552-557
Number of pages6
JournalMolecular medicine (Cambridge, Mass.)
Volume16
Issue number11-12
DOIs
Publication statusPublished - Nov 2010

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Molecular Medicine
  • Genetics(clinical)

Fingerprint Dive into the research topics of 'Interleukin-1β and interleukin-6 in arthritis animal models: Roles in the early phase of transition from acute to chronic inflammation and relevance for human rheumatoid arthritis'. Together they form a unique fingerprint.

  • Cite this