Interleukin-1β and interleukin-6 mRNA are expressed in human glioblastoma and neuroblastoma cells respectively

A. Stephanou, R. A. Knight, M. Annicchiarico-Petruzzelli, A. Finazzi-Agro, S. L. Lightmann, G. Melino

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Abstract

We report the expression of different interleukin (IL) in four human glioblastoma and neuroblastoma cell lines. The glioblastoma cell line LI, expresses IL-1β and IL-6 mRNA, though not IL-2 and IL-4. The expression of the former gene is modulated by retinoic acid. Two cell clones [BE(2)-C and BE(2)-M17] as well as the neuroblastoma cell line SK-N-BE(2), from which both clones were derived, express IL-6 mRNA, but not IL-1β, IL-2 or IL-4. Both IL-1β and IL-6 cytokines are known to increase hypothalamic CRH mRNA, a gene reported to be expressed in all these cell lines. The production of both cytokines and neuropeptides indicates a complex dialogue between tumour cells and anti-tumour immunity.

Original languageEnglish
Pages (from-to)129-133
Number of pages5
JournalFunctional Neurology
Volume7
Issue number2
Publication statusPublished - 1992

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ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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