Interleukin-1 alpha and beta, TNF-alpha and HTTLPR gene variants study on alcohol toxicity and detoxification outcome

Alessandro Serretti, Ioannis Liappas, Laura Mandelli, Diego Albani, Gianluigi Forloni, Petros Malitas, Christina Piperi, Aikaterini Zisaki, Elias O. Tzavellas, Zeta Papadopoulou-Daifoti, Francesca Prato, Sara Batelli, Marzia Pesaresi, Anastasios Kalofoutis

Research output: Contribution to journalArticlepeer-review

Abstract

Genetic factors may influence the liability to treatment outcome and medical complications in alcoholism. In the present study we investigated the IL-1A rs1800587, IL-1B rs3087258, TNF-α rs1799724 and the HTTLPR variants in a sample of 64 alcohol dependents and 47 relatives versus a set of clinical parameters and outcome measures. Alcohol dependents had a less favorable clinical profile compared to relatives (higher cholesterol, triglycerides, glucose, glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, gamma-glutamyltransferase). After detoxification, all clinical indexes improved and hepatic enzyme levels were similar in alcohol dependents and relatives, except for the GGT that remained significantly higher in alcohol dependents. Alcoholic depressive and anxiety scores were significantly reduced after detoxification. IL-1A, IL-1B, TNF-α and HTTLPR variants were not associated with any baseline clinical index or change after detoxification. In our sample IL-1A, IL-1B, TNF-α and HTTLPR do not appear as liability factors for alcohol toxicity or detoxification outcome, however the small sample size may influence the observed results.

Original languageEnglish
Pages (from-to)107-112
Number of pages6
JournalNeuroscience Letters
Volume406
Issue number1-2
DOIs
Publication statusPublished - Oct 2 2006

Keywords

  • Alcohol dependence
  • Detoxification
  • Gene
  • Interleukin

ASJC Scopus subject areas

  • Neuroscience(all)

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