TY - JOUR
T1 - Interleukin-1 alpha and beta, TNF-alpha and HTTLPR gene variants study on alcohol toxicity and detoxification outcome
AU - Serretti, Alessandro
AU - Liappas, Ioannis
AU - Mandelli, Laura
AU - Albani, Diego
AU - Forloni, Gianluigi
AU - Malitas, Petros
AU - Piperi, Christina
AU - Zisaki, Aikaterini
AU - Tzavellas, Elias O.
AU - Papadopoulou-Daifoti, Zeta
AU - Prato, Francesca
AU - Batelli, Sara
AU - Pesaresi, Marzia
AU - Kalofoutis, Anastasios
PY - 2006/10/2
Y1 - 2006/10/2
N2 - Genetic factors may influence the liability to treatment outcome and medical complications in alcoholism. In the present study we investigated the IL-1A rs1800587, IL-1B rs3087258, TNF-α rs1799724 and the HTTLPR variants in a sample of 64 alcohol dependents and 47 relatives versus a set of clinical parameters and outcome measures. Alcohol dependents had a less favorable clinical profile compared to relatives (higher cholesterol, triglycerides, glucose, glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, gamma-glutamyltransferase). After detoxification, all clinical indexes improved and hepatic enzyme levels were similar in alcohol dependents and relatives, except for the GGT that remained significantly higher in alcohol dependents. Alcoholic depressive and anxiety scores were significantly reduced after detoxification. IL-1A, IL-1B, TNF-α and HTTLPR variants were not associated with any baseline clinical index or change after detoxification. In our sample IL-1A, IL-1B, TNF-α and HTTLPR do not appear as liability factors for alcohol toxicity or detoxification outcome, however the small sample size may influence the observed results.
AB - Genetic factors may influence the liability to treatment outcome and medical complications in alcoholism. In the present study we investigated the IL-1A rs1800587, IL-1B rs3087258, TNF-α rs1799724 and the HTTLPR variants in a sample of 64 alcohol dependents and 47 relatives versus a set of clinical parameters and outcome measures. Alcohol dependents had a less favorable clinical profile compared to relatives (higher cholesterol, triglycerides, glucose, glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, gamma-glutamyltransferase). After detoxification, all clinical indexes improved and hepatic enzyme levels were similar in alcohol dependents and relatives, except for the GGT that remained significantly higher in alcohol dependents. Alcoholic depressive and anxiety scores were significantly reduced after detoxification. IL-1A, IL-1B, TNF-α and HTTLPR variants were not associated with any baseline clinical index or change after detoxification. In our sample IL-1A, IL-1B, TNF-α and HTTLPR do not appear as liability factors for alcohol toxicity or detoxification outcome, however the small sample size may influence the observed results.
KW - Alcohol dependence
KW - Detoxification
KW - Gene
KW - Interleukin
UR - http://www.scopus.com/inward/record.url?scp=33747759668&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33747759668&partnerID=8YFLogxK
U2 - 10.1016/j.neulet.2006.07.003
DO - 10.1016/j.neulet.2006.07.003
M3 - Article
C2 - 16916584
AN - SCOPUS:33747759668
VL - 406
SP - 107
EP - 112
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 1-2
ER -