Interleukin-1 and glomerular mesangial cells

Carla Zoja, Alessandro Rambaldi, Giuseppe Remuzzi

Research output: Contribution to journalArticlepeer-review

Abstract

Our previous in vitro study demonstrated that interleukin-1 (IL-1) stimulates gene expression and production of leukocyte chemotactic factors, colony-stimulating factors and interleu- kin-6 in human mesangial cells in culture. Here we investigated whether IL-1 regulates its own gene expression in human mesangial cells. Northern blot experiments showed that IL-1 induced IL-1 mRNA expression in a dose-dependent manner. The action of IL-1 on mesangial cells was mediated through the IL-1 receptor type I, which is constitutively expressed by mesangial cells. Recombinant IL-1 receptor antagonist blocked the IL-1 mRNA as well as interleukin-6 and interleukin-8 gene expression induced by IL-1. These data support the crucial role played by IL-1 in regulating mesangial cell cytokine genes within the glomerulus during immunological or inflammatory processes.

Original languageEnglish
Pages (from-to)89-92
Number of pages4
JournalKidney and Blood Pressure Research
Volume16
Issue number1-2
DOIs
Publication statusPublished - 1993

Keywords

  • Interleukin-1 gene
  • Interleukin-1 receptor
  • Interleukin-1 receptor antagonist
  • Interleukin-6 gene
  • Interleukin-8 gene
  • Mesangial cells

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Nephrology

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