Abstract
Forty years after its naming, interleukin-1 (IL-1) is experiencing a renaissance brought on by the growing understanding of its context-dependent roles and advances in the clinic. Recent studies have identified important roles for members of the IL-1 family-IL-18, IL-33, IL-36, IL-37, and IL-38-in inflammation and immunity. Here, we review the complex functions of IL-1 family members in the orchestration of innate and adaptive immune responses and their diversity and plasticity. We discuss the varied roles of IL-1 family members in immune homeostasis and their contribution to pathologies, including autoimmunity and auto-inflammation, dysmetabolism, cardiovascular disorders, and cancer. The trans-disease therapeutic activity of anti-IL-1 strategies argues for immunity and inflammation as a metanarrative of modern medicine.
Original language | English |
---|---|
Pages (from-to) | 778-795 |
Number of pages | 18 |
Journal | Immunity |
Volume | 50 |
Issue number | 4 |
DOIs | |
Publication status | Published - Apr 16 2019 |
Keywords
- Adaptive Immunity/immunology
- Animals
- Cardiovascular Diseases/immunology
- Cytokines/genetics
- Gastrointestinal Diseases/immunology
- Hematopoiesis/immunology
- Humans
- Immunity, Innate/immunology
- Inflammation/immunology
- Interleukin-1/immunology
- Lymphocytes/immunology
- Mice
- Mice, Knockout
- Multigene Family
- Neoplasms/immunology
- Neurodegenerative Diseases/immunology
- Receptors, Cytokine/genetics