Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity

Alberto Mantovani; Charles A Dinarello; Martina Molgora; Cecilia Garlanda

doi:10.1016/j.immuni.2019.03.012

Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity

Alberto Mantovani, Charles A Dinarello, Martina Molgora, Cecilia Garlanda

Istituto Clinico Humanitas

Research output: Contribution to journal › Review article

Abstract

Forty years after its naming, interleukin-1 (IL-1) is experiencing a renaissance brought on by the growing understanding of its context-dependent roles and advances in the clinic. Recent studies have identified important roles for members of the IL-1 family-IL-18, IL-33, IL-36, IL-37, and IL-38-in inflammation and immunity. Here, we review the complex functions of IL-1 family members in the orchestration of innate and adaptive immune responses and their diversity and plasticity. We discuss the varied roles of IL-1 family members in immune homeostasis and their contribution to pathologies, including autoimmunity and auto-inflammation, dysmetabolism, cardiovascular disorders, and cancer. The trans-disease therapeutic activity of anti-IL-1 strategies argues for immunity and inflammation as a metanarrative of modern medicine.

Original language	English
Pages (from-to)	778-795
Number of pages	18
Journal	Immunity
Volume	50
Issue number	4
DOIs	https://doi.org/10.1016/j.immuni.2019.03.012
Publication status	Published - Apr 16 2019

Keywords

Adaptive Immunity/immunology
Animals
Cardiovascular Diseases/immunology
Cytokines/genetics
Gastrointestinal Diseases/immunology
Hematopoiesis/immunology
Humans
Immunity, Innate/immunology
Inflammation/immunology
Interleukin-1/immunology
Lymphocytes/immunology
Mice
Mice, Knockout
Multigene Family
Neoplasms/immunology
Neurodegenerative Diseases/immunology
Receptors, Cytokine/genetics

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Mantovani, A., Dinarello, C. A., Molgora, M., & Garlanda, C. (2019). Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity. Immunity, 50(4), 778-795. https://doi.org/10.1016/j.immuni.2019.03.012

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abstract = "Forty years after its naming, interleukin-1 (IL-1) is experiencing a renaissance brought on by the growing understanding of its context-dependent roles and advances in the clinic. Recent studies have identified important roles for members of the IL-1 family-IL-18, IL-33, IL-36, IL-37, and IL-38-in inflammation and immunity. Here, we review the complex functions of IL-1 family members in the orchestration of innate and adaptive immune responses and their diversity and plasticity. We discuss the varied roles of IL-1 family members in immune homeostasis and their contribution to pathologies, including autoimmunity and auto-inflammation, dysmetabolism, cardiovascular disorders, and cancer. The trans-disease therapeutic activity of anti-IL-1 strategies argues for immunity and inflammation as a metanarrative of modern medicine.",

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author = "Alberto Mantovani and Dinarello, {Charles A} and Martina Molgora and Cecilia Garlanda",

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T1 - Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity

AU - Mantovani, Alberto

AU - Dinarello, Charles A

AU - Molgora, Martina

AU - Garlanda, Cecilia

PY - 2019/4/16

Y1 - 2019/4/16

N2 - Forty years after its naming, interleukin-1 (IL-1) is experiencing a renaissance brought on by the growing understanding of its context-dependent roles and advances in the clinic. Recent studies have identified important roles for members of the IL-1 family-IL-18, IL-33, IL-36, IL-37, and IL-38-in inflammation and immunity. Here, we review the complex functions of IL-1 family members in the orchestration of innate and adaptive immune responses and their diversity and plasticity. We discuss the varied roles of IL-1 family members in immune homeostasis and their contribution to pathologies, including autoimmunity and auto-inflammation, dysmetabolism, cardiovascular disorders, and cancer. The trans-disease therapeutic activity of anti-IL-1 strategies argues for immunity and inflammation as a metanarrative of modern medicine.

AB - Forty years after its naming, interleukin-1 (IL-1) is experiencing a renaissance brought on by the growing understanding of its context-dependent roles and advances in the clinic. Recent studies have identified important roles for members of the IL-1 family-IL-18, IL-33, IL-36, IL-37, and IL-38-in inflammation and immunity. Here, we review the complex functions of IL-1 family members in the orchestration of innate and adaptive immune responses and their diversity and plasticity. We discuss the varied roles of IL-1 family members in immune homeostasis and their contribution to pathologies, including autoimmunity and auto-inflammation, dysmetabolism, cardiovascular disorders, and cancer. The trans-disease therapeutic activity of anti-IL-1 strategies argues for immunity and inflammation as a metanarrative of modern medicine.

KW - Adaptive Immunity/immunology

KW - Animals

KW - Cardiovascular Diseases/immunology

KW - Cytokines/genetics

KW - Gastrointestinal Diseases/immunology

KW - Hematopoiesis/immunology

KW - Humans

KW - Immunity, Innate/immunology

KW - Inflammation/immunology

KW - Interleukin-1/immunology

KW - Lymphocytes/immunology

KW - Mice

KW - Mice, Knockout

KW - Multigene Family

KW - Neoplasms/immunology

KW - Neurodegenerative Diseases/immunology

KW - Receptors, Cytokine/genetics

U2 - 10.1016/j.immuni.2019.03.012

DO - 10.1016/j.immuni.2019.03.012

M3 - Review article

C2 - 30995499

VL - 50

SP - 778

EP - 795

JO - Immunity

JF - Immunity

SN - 1074-7613

IS - 4

ER -