Interleukin-1-beta, interleukin-6, and interferon-gamma in suction blister fluids of involved skin and in sera of psoriatic patients

C. Bonifati, F. Ameglio, M. Carducci, G. Sacerdoti, M. Pietravalle, M. Fazio

Research output: Contribution to journalArticlepeer-review

Abstract

Interleukin-1-beta (IL-1-beta), Interleukin-6 (IL-6) and Interferon-gamma (IFN-gamma) were measured by enzyme immunoassay (EIA) methods in blister fluids (BFs) obtained from both involved (ISBF) and non-involved skin (USBF) and in sera from 14 psoriastic patients. The same determinations were carried out in 14 sera and in 5 suction blister fluids from 14 normal subjects. IL-6 was always detectable in all skin fluids and in 3 psoriasis sera. IL-1-beta was measured only in 5 ISBFs and in 5 sera from the same patients. IFN-gamma was preasent in 11 ISBFs, in 5 USBFs and in 5 sera. The analysis of the levels found in the samples shows: 1) a local production of these cytokines, 2) the presence of detectable amounts of IL-6 and IFN-gamma in USBFs, and 3) a significant correlation between the IL-6 levels in the ISBFs and erythema score.

Original languageEnglish
Pages (from-to)23-24
Number of pages2
JournalActa Dermato-Venereologica, Supplement
Issue number186
Publication statusPublished - 1994

Keywords

  • blister fluids
  • IL-1-beta and IFN-gamma
  • IL-6
  • psoriasis

ASJC Scopus subject areas

  • Dermatology

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