Abstract
Interleukin-1-beta (IL-1-beta), Interleukin-6 (IL-6) and Interferon-gamma (IFN-gamma) were measured by enzyme immunoassay (EIA) methods in blister fluids (BFs) obtained from both involved (ISBF) and non-involved skin (USBF) and in sera from 14 psoriastic patients. The same determinations were carried out in 14 sera and in 5 suction blister fluids from 14 normal subjects. IL-6 was always detectable in all skin fluids and in 3 psoriasis sera. IL-1-beta was measured only in 5 ISBFs and in 5 sera from the same patients. IFN-gamma was preasent in 11 ISBFs, in 5 USBFs and in 5 sera. The analysis of the levels found in the samples shows: 1) a local production of these cytokines, 2) the presence of detectable amounts of IL-6 and IFN-gamma in USBFs, and 3) a significant correlation between the IL-6 levels in the ISBFs and erythema score.
| Original language | English |
|---|---|
| Pages (from-to) | 23-24 |
| Number of pages | 2 |
| Journal | Acta Dermato-Venereologica, Supplement |
| Issue number | 186 |
| Publication status | Published - 1994 |
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Keywords
- blister fluids
- IL-1-beta and IFN-gamma
- IL-6
- psoriasis
ASJC Scopus subject areas
- Dermatology
Cite this
Interleukin-1-beta, interleukin-6, and interferon-gamma in suction blister fluids of involved skin and in sera of psoriatic patients. / Bonifati, C.; Ameglio, F.; Carducci, M.; Sacerdoti, G.; Pietravalle, M.; Fazio, M.
In: Acta Dermato-Venereologica, Supplement, No. 186, 1994, p. 23-24.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Interleukin-1-beta, interleukin-6, and interferon-gamma in suction blister fluids of involved skin and in sera of psoriatic patients
AU - Bonifati, C.
AU - Ameglio, F.
AU - Carducci, M.
AU - Sacerdoti, G.
AU - Pietravalle, M.
AU - Fazio, M.
PY - 1994
Y1 - 1994
N2 - Interleukin-1-beta (IL-1-beta), Interleukin-6 (IL-6) and Interferon-gamma (IFN-gamma) were measured by enzyme immunoassay (EIA) methods in blister fluids (BFs) obtained from both involved (ISBF) and non-involved skin (USBF) and in sera from 14 psoriastic patients. The same determinations were carried out in 14 sera and in 5 suction blister fluids from 14 normal subjects. IL-6 was always detectable in all skin fluids and in 3 psoriasis sera. IL-1-beta was measured only in 5 ISBFs and in 5 sera from the same patients. IFN-gamma was preasent in 11 ISBFs, in 5 USBFs and in 5 sera. The analysis of the levels found in the samples shows: 1) a local production of these cytokines, 2) the presence of detectable amounts of IL-6 and IFN-gamma in USBFs, and 3) a significant correlation between the IL-6 levels in the ISBFs and erythema score.
AB - Interleukin-1-beta (IL-1-beta), Interleukin-6 (IL-6) and Interferon-gamma (IFN-gamma) were measured by enzyme immunoassay (EIA) methods in blister fluids (BFs) obtained from both involved (ISBF) and non-involved skin (USBF) and in sera from 14 psoriastic patients. The same determinations were carried out in 14 sera and in 5 suction blister fluids from 14 normal subjects. IL-6 was always detectable in all skin fluids and in 3 psoriasis sera. IL-1-beta was measured only in 5 ISBFs and in 5 sera from the same patients. IFN-gamma was preasent in 11 ISBFs, in 5 USBFs and in 5 sera. The analysis of the levels found in the samples shows: 1) a local production of these cytokines, 2) the presence of detectable amounts of IL-6 and IFN-gamma in USBFs, and 3) a significant correlation between the IL-6 levels in the ISBFs and erythema score.
KW - blister fluids
KW - IL-1-beta and IFN-gamma
KW - IL-6
KW - psoriasis
UR - http://www.scopus.com/inward/record.url?scp=0028186114&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028186114&partnerID=8YFLogxK
M3 - Article
C2 - 8073828
AN - SCOPUS:0028186114
SP - 23
EP - 24
JO - Acta Dermato-Venereologica, Supplement
JF - Acta Dermato-Venereologica, Supplement
SN - 0365-8341
IS - 186
ER -