Interleukin-1-beta, interleukin-6, and interferon-gamma in suction blister fluids of involved skin and in sera of psoriatic patients

C. Bonifati, F. Ameglio, M. Carducci, G. Sacerdoti, M. Pietravalle, M. Fazio

Research output: Contribution to journalArticle

Abstract

Interleukin-1-beta (IL-1-beta), Interleukin-6 (IL-6) and Interferon-gamma (IFN-gamma) were measured by enzyme immunoassay (EIA) methods in blister fluids (BFs) obtained from both involved (ISBF) and non-involved skin (USBF) and in sera from 14 psoriastic patients. The same determinations were carried out in 14 sera and in 5 suction blister fluids from 14 normal subjects. IL-6 was always detectable in all skin fluids and in 3 psoriasis sera. IL-1-beta was measured only in 5 ISBFs and in 5 sera from the same patients. IFN-gamma was preasent in 11 ISBFs, in 5 USBFs and in 5 sera. The analysis of the levels found in the samples shows: 1) a local production of these cytokines, 2) the presence of detectable amounts of IL-6 and IFN-gamma in USBFs, and 3) a significant correlation between the IL-6 levels in the ISBFs and erythema score.

Original languageEnglish
Pages (from-to)23-24
Number of pages2
JournalActa Dermato-Venereologica, Supplement
Issue number186
Publication statusPublished - 1994

Fingerprint

Suction
Blister
Interleukin-1beta
Interferon-gamma
Interleukin-6
Skin
Serum
Erythema
Immunoenzyme Techniques
Psoriasis
Cytokines

Keywords

  • blister fluids
  • IL-1-beta and IFN-gamma
  • IL-6
  • psoriasis

ASJC Scopus subject areas

  • Dermatology

Cite this

Interleukin-1-beta, interleukin-6, and interferon-gamma in suction blister fluids of involved skin and in sera of psoriatic patients. / Bonifati, C.; Ameglio, F.; Carducci, M.; Sacerdoti, G.; Pietravalle, M.; Fazio, M.

In: Acta Dermato-Venereologica, Supplement, No. 186, 1994, p. 23-24.

Research output: Contribution to journalArticle

@article{bfc36d2d105e423e9319cd6c5b869f42,
title = "Interleukin-1-beta, interleukin-6, and interferon-gamma in suction blister fluids of involved skin and in sera of psoriatic patients",
abstract = "Interleukin-1-beta (IL-1-beta), Interleukin-6 (IL-6) and Interferon-gamma (IFN-gamma) were measured by enzyme immunoassay (EIA) methods in blister fluids (BFs) obtained from both involved (ISBF) and non-involved skin (USBF) and in sera from 14 psoriastic patients. The same determinations were carried out in 14 sera and in 5 suction blister fluids from 14 normal subjects. IL-6 was always detectable in all skin fluids and in 3 psoriasis sera. IL-1-beta was measured only in 5 ISBFs and in 5 sera from the same patients. IFN-gamma was preasent in 11 ISBFs, in 5 USBFs and in 5 sera. The analysis of the levels found in the samples shows: 1) a local production of these cytokines, 2) the presence of detectable amounts of IL-6 and IFN-gamma in USBFs, and 3) a significant correlation between the IL-6 levels in the ISBFs and erythema score.",
keywords = "blister fluids, IL-1-beta and IFN-gamma, IL-6, psoriasis",
author = "C. Bonifati and F. Ameglio and M. Carducci and G. Sacerdoti and M. Pietravalle and M. Fazio",
year = "1994",
language = "English",
pages = "23--24",
journal = "Acta Dermato-Venereologica, Supplement",
issn = "0365-8341",
publisher = "Society for the Publication of Acta Dermato-Venereologica",
number = "186",

}

TY - JOUR

T1 - Interleukin-1-beta, interleukin-6, and interferon-gamma in suction blister fluids of involved skin and in sera of psoriatic patients

AU - Bonifati, C.

AU - Ameglio, F.

AU - Carducci, M.

AU - Sacerdoti, G.

AU - Pietravalle, M.

AU - Fazio, M.

PY - 1994

Y1 - 1994

N2 - Interleukin-1-beta (IL-1-beta), Interleukin-6 (IL-6) and Interferon-gamma (IFN-gamma) were measured by enzyme immunoassay (EIA) methods in blister fluids (BFs) obtained from both involved (ISBF) and non-involved skin (USBF) and in sera from 14 psoriastic patients. The same determinations were carried out in 14 sera and in 5 suction blister fluids from 14 normal subjects. IL-6 was always detectable in all skin fluids and in 3 psoriasis sera. IL-1-beta was measured only in 5 ISBFs and in 5 sera from the same patients. IFN-gamma was preasent in 11 ISBFs, in 5 USBFs and in 5 sera. The analysis of the levels found in the samples shows: 1) a local production of these cytokines, 2) the presence of detectable amounts of IL-6 and IFN-gamma in USBFs, and 3) a significant correlation between the IL-6 levels in the ISBFs and erythema score.

AB - Interleukin-1-beta (IL-1-beta), Interleukin-6 (IL-6) and Interferon-gamma (IFN-gamma) were measured by enzyme immunoassay (EIA) methods in blister fluids (BFs) obtained from both involved (ISBF) and non-involved skin (USBF) and in sera from 14 psoriastic patients. The same determinations were carried out in 14 sera and in 5 suction blister fluids from 14 normal subjects. IL-6 was always detectable in all skin fluids and in 3 psoriasis sera. IL-1-beta was measured only in 5 ISBFs and in 5 sera from the same patients. IFN-gamma was preasent in 11 ISBFs, in 5 USBFs and in 5 sera. The analysis of the levels found in the samples shows: 1) a local production of these cytokines, 2) the presence of detectable amounts of IL-6 and IFN-gamma in USBFs, and 3) a significant correlation between the IL-6 levels in the ISBFs and erythema score.

KW - blister fluids

KW - IL-1-beta and IFN-gamma

KW - IL-6

KW - psoriasis

UR - http://www.scopus.com/inward/record.url?scp=0028186114&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028186114&partnerID=8YFLogxK

M3 - Article

C2 - 8073828

AN - SCOPUS:0028186114

SP - 23

EP - 24

JO - Acta Dermato-Venereologica, Supplement

JF - Acta Dermato-Venereologica, Supplement

SN - 0365-8341

IS - 186

ER -