Interleukin-1 family cytokines and mast cells: activation and inhibition

C E Gallenga; F Pandolfi; Al Caraffa; S K Kritas; G Ronconi; E Toniato; S Martinotti; P Conti

Interleukin-1 family cytokines and mast cells: activation and inhibition

C E Gallenga, F Pandolfi, Al Caraffa, S K Kritas, G Ronconi, E Toniato, S Martinotti, P Conti

Research output: Contribution to journal › Article › peer-review

Abstract

Activated mast cells (MCs) secrete a number of compounds including pro-inflammatory and anti-inflammatory cytokines. MCs are a potential source of cytokines and chemokines which participate in allergic reactions and inflammation. MCs can be activated by IgE through its receptor FceRI, but also by Toll-like receptors and/or interleukin (IL)-1. MCs can be a target for both pro-inflammatory and anti-inflammatory cytokines. IL-1 activates MCs to release inflammatory chemical mediators, and cytokines/chemokines, an effect which can be potentially inhibited by IL-37. In addition, IL-36 is also a powerful cytokine with a pro-inflammatory activity. IL-38 binds IL-36R and inhibits the pro-inflammatory activity of IL-36, thus performing a therapeutic action. In this article we review the role of MCs in relation to pro-inflammatory and anti-inflammatory IL-1 family member cytokines and a possible therapeutic effect in inflammatory disorders.

Original language	English
Pages (from-to)	1-6
Number of pages	6
Journal	Journal of Biological Regulators and Homeostatic Agents
Volume	33
Issue number	1
Publication status	Published - Jan 19 2019
Externally published	Yes

Keywords

Chemokines/immunology
Cytokines/immunology
Humans
Inflammation/immunology
Interleukin-1/immunology
Interleukins/immunology
Mast Cells/immunology

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title = "Interleukin-1 family cytokines and mast cells: activation and inhibition",

abstract = "Activated mast cells (MCs) secrete a number of compounds including pro-inflammatory and anti-inflammatory cytokines. MCs are a potential source of cytokines and chemokines which participate in allergic reactions and inflammation. MCs can be activated by IgE through its receptor FceRI, but also by Toll-like receptors and/or interleukin (IL)-1. MCs can be a target for both pro-inflammatory and anti-inflammatory cytokines. IL-1 activates MCs to release inflammatory chemical mediators, and cytokines/chemokines, an effect which can be potentially inhibited by IL-37. In addition, IL-36 is also a powerful cytokine with a pro-inflammatory activity. IL-38 binds IL-36R and inhibits the pro-inflammatory activity of IL-36, thus performing a therapeutic action. In this article we review the role of MCs in relation to pro-inflammatory and anti-inflammatory IL-1 family member cytokines and a possible therapeutic effect in inflammatory disorders.",

keywords = "Chemokines/immunology, Cytokines/immunology, Humans, Inflammation/immunology, Interleukin-1/immunology, Interleukins/immunology, Mast Cells/immunology",

author = "Gallenga, {C E} and F Pandolfi and Al Caraffa and Kritas, {S K} and G Ronconi and E Toniato and S Martinotti and P Conti",

year = "2019",

month = jan,

day = "19",

language = "English",

volume = "33",

pages = "1--6",

journal = "Journal of Biological Regulators and Homeostatic Agents",

issn = "0393-974X",

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TY - JOUR

T1 - Interleukin-1 family cytokines and mast cells

T2 - activation and inhibition

AU - Gallenga, C E

AU - Pandolfi, F

AU - Caraffa, Al

AU - Kritas, S K

AU - Ronconi, G

AU - Toniato, E

AU - Martinotti, S

AU - Conti, P

PY - 2019/1/19

Y1 - 2019/1/19

N2 - Activated mast cells (MCs) secrete a number of compounds including pro-inflammatory and anti-inflammatory cytokines. MCs are a potential source of cytokines and chemokines which participate in allergic reactions and inflammation. MCs can be activated by IgE through its receptor FceRI, but also by Toll-like receptors and/or interleukin (IL)-1. MCs can be a target for both pro-inflammatory and anti-inflammatory cytokines. IL-1 activates MCs to release inflammatory chemical mediators, and cytokines/chemokines, an effect which can be potentially inhibited by IL-37. In addition, IL-36 is also a powerful cytokine with a pro-inflammatory activity. IL-38 binds IL-36R and inhibits the pro-inflammatory activity of IL-36, thus performing a therapeutic action. In this article we review the role of MCs in relation to pro-inflammatory and anti-inflammatory IL-1 family member cytokines and a possible therapeutic effect in inflammatory disorders.

AB - Activated mast cells (MCs) secrete a number of compounds including pro-inflammatory and anti-inflammatory cytokines. MCs are a potential source of cytokines and chemokines which participate in allergic reactions and inflammation. MCs can be activated by IgE through its receptor FceRI, but also by Toll-like receptors and/or interleukin (IL)-1. MCs can be a target for both pro-inflammatory and anti-inflammatory cytokines. IL-1 activates MCs to release inflammatory chemical mediators, and cytokines/chemokines, an effect which can be potentially inhibited by IL-37. In addition, IL-36 is also a powerful cytokine with a pro-inflammatory activity. IL-38 binds IL-36R and inhibits the pro-inflammatory activity of IL-36, thus performing a therapeutic action. In this article we review the role of MCs in relation to pro-inflammatory and anti-inflammatory IL-1 family member cytokines and a possible therapeutic effect in inflammatory disorders.

KW - Chemokines/immunology

KW - Cytokines/immunology

KW - Humans

KW - Inflammation/immunology

KW - Interleukin-1/immunology

KW - Interleukins/immunology

KW - Mast Cells/immunology

M3 - Article

C2 - 30656901

VL - 33

SP - 1

EP - 6

JO - Journal of Biological Regulators and Homeostatic Agents

JF - Journal of Biological Regulators and Homeostatic Agents

SN - 0393-974X

IS - 1

ER -