Interleukin-1 family cytokines and mast cells: activation and inhibition

C E Gallenga, F Pandolfi, Al Caraffa, S K Kritas, G Ronconi, E Toniato, S Martinotti, P Conti

Research output: Contribution to journalArticlepeer-review

Abstract

Activated mast cells (MCs) secrete a number of compounds including pro-inflammatory and anti-inflammatory cytokines. MCs are a potential source of cytokines and chemokines which participate in allergic reactions and inflammation. MCs can be activated by IgE through its receptor FceRI, but also by Toll-like receptors and/or interleukin (IL)-1. MCs can be a target for both pro-inflammatory and anti-inflammatory cytokines. IL-1 activates MCs to release inflammatory chemical mediators, and cytokines/chemokines, an effect which can be potentially inhibited by IL-37. In addition, IL-36 is also a powerful cytokine with a pro-inflammatory activity. IL-38 binds IL-36R and inhibits the pro-inflammatory activity of IL-36, thus performing a therapeutic action. In this article we review the role of MCs in relation to pro-inflammatory and anti-inflammatory IL-1 family member cytokines and a possible therapeutic effect in inflammatory disorders.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalJournal of Biological Regulators and Homeostatic Agents
Volume33
Issue number1
Publication statusPublished - Jan 19 2019
Externally publishedYes

Keywords

  • Chemokines/immunology
  • Cytokines/immunology
  • Humans
  • Inflammation/immunology
  • Interleukin-1/immunology
  • Interleukins/immunology
  • Mast Cells/immunology

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