Interleukin-1 gene cluster polymorphisms and risk of coronary artery disease

Branislav Vohnout, Augusto Di Castelnuovo, Roberto Trotta, Andria D'Orazio, Gaetano Panniteri, Anna Montali, Maria Benedetta Donati, Marcello Arca, Licia Iacoviello

Research output: Contribution to journalArticlepeer-review

Abstract

Background and Objectives. The pro-inflammatory cytokine interleukin (IL)-1 has been suggested to play a role in atherosclerosis. Several genetic polymorphisms have been described in the genes of the IL-1 cluster and associations with coronary artery disease (CAD) have been reported, although with contrasting results. Design and Methods. The associations of a variable number tandem repeat (86bp) polymorphism in intron 2 of interleukin-1 receptor antagonist (IL1-RA) and of the -511 C/T polymorphism of IL-1β with the risk of CAD were studied. Three hundred and thirty-five case (CAD+) patients with angiographically documented CAD (stenosis >50% in at least one major coronary artery) were compared with 205 unrelated individuals free of CAD signs at angiogram (CAD-controls). One hundred and two (30.5%) CAD+ patients had single-vessel disease (SVD) and 233 (69.5%) multiple-vessel disease (MVD). Results. There was no statistically significant difference in either genotype distribution or allele frequency of both IL-1 RA and IL-1β -511 C/T polymorphisms between CAD+ cases and CAD-controls. Moreover in multivariate analysis, adjusting for multiple comparisons and confounding factors, no difference was found in IL-1 RA genotype distribution between patients with SVD or MVD. Interpretation and Conclusions. Our study does not support the association between IL-1 RA intron 2 VNTR and IL-1β -511 C/T polymorphisms and the risk of CAD in individuals undergoing coronary angiography.

Original languageEnglish
Pages (from-to)54-60
Number of pages7
JournalHaematologica
Volume88
Issue number1
Publication statusPublished - Feb 1 2003

Keywords

  • Coronary artery disease
  • Interleukin-1 receptor antagonist gene
  • Interleukin-1β
  • Polymorphism

ASJC Scopus subject areas

  • Hematology

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