Interleukin 1 induces an autocrine loop hepatocyte growth factor/c-Met in murine Kaposi-like spindle cells

Jam Maier, M. Mariotti, P. M. Comoglio, M. R. Soria

Research output: Contribution to journalArticlepeer-review

Abstract

Several cytokines, growth factors and the HIV transactivator Tat were shown to be involved in the pathogenesis of Kaposi's sarcoma. BKV/tat transgenic mice develop Kaposi's sarcoma-like lesions, and spindle-shaped cells (TTB) have been derived from these lesions. Here we show that TTB cells co-express hepatocyte growth factor (HGF) and its receptor, the product of the oncogene c-Met. An autocrine loop HGF/Met sustains spindle cell proliferation in vitro; indeed, an antisense oligomer targeted against HGF markedly inhibited cell growth. Moreover, HGF and Met are overexpressed after exposing TTB cells to the proinflammatory cytokine interleukin 1 (IL-1). We argue that upon exposure to IL-1, an HGF/Met autocrine loop is induced which could explain the appearance of multiple foci of uncontrolled growth. In addition, due to its angiogenic activity, HGF may also sustain the neovascularization typical of Kaposi's sarcoma lesions.

Original languageEnglish
Pages (from-to)1009-1015
Number of pages7
JournalOncogene
Volume13
Issue number5
Publication statusPublished - 1996

Keywords

  • Autocrine loop
  • c-Met
  • Hepatocyte growth factor
  • Interleukin-1α
  • Kaposi's sarcoma

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research
  • Genetics

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