Interleukin-1 induces changes in sleep, brain temperature, and serotonergic metabolism

Carmelina Gemma, Luca Imeri, Maria Grazia De Simoni, Mauro Mancia

Research output: Contribution to journalArticlepeer-review


Simultaneous recordings of sleep-wake activity and of serotonergic metabolism in the medial preoptic area were performed in freely moving rats after the intracerebroventricular injection of interleukin-1 (IL-1) at dark onset. IL-1 (2.5 ng) induced a biphasic increase in slow-wave sleep and an early increase in serotonergic metabolism starting 30 min postinjection. Phasic, state-specific changes (which have been described in spontaneous sleep) were superimposed on this tonic, overall increase in serotonergic metabolism. IL-1 (25 ng) induced an increase in wakefulness and a delayed increase in serotonergic metabolism, which started 120 min postinjection. This suggests that the time course of the serotonergic activation could play a role in mediating IL-1 effects on sleep. Both doses of IL-1 induced a similar and significant increase in brain cortical temperature, suggesting that IL-1 effects on sleep are not a secondary effect of the increase in cortical temperature and that the serotonergic system is not involved in IL- 1-induced fever.

Original languageEnglish
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Issue number2 41-2
Publication statusPublished - 1997


  • 5-hydroxyindole acetic acid
  • cytokine
  • rat
  • sleep-wake cycle
  • thermoregulation

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


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