Interleukin 1 promotes tumor cell adhesion to cultured human endothelial cells

E. Dejana, F. Bertocchi, M. C. Bortolami, A. Regonesi, A. Tonta, F. Breviario, R. Giavazzi

Research output: Contribution to journalArticlepeer-review

Abstract

We report that IL 1 acts on the endothelium, inducing a long-lasting increase in its adhesiveness to tumor cells. Selective pretreatment of cultured human umbilical vein endothelial cells (EC) with IL 1 caused a significant increase in adhesion of three human colorectal carcinoma (HT-29, HCC-P2988, and HCC-M1410) cell lines and one human melanoma (A-375) cell line. Tumor necrosis factor (TNF) was as effective as IL 1 in promoting tumor cell adhesion to EC, whereas IFN γ and IL 2 were inactive. The IL 1 and TNF induction of EC adhesiveness was both concentration (threshold concentration 1 U/ml) and time dependent (peak 4-6 h), reversible within 24 h, and blocked by a protein synthesis inhibitor. The IL 1 and TNF action on EC may play a role in tumor cell lodgment.

Original languageEnglish
Pages (from-to)1466-1470
Number of pages5
JournalJournal of Clinical Investigation
Volume82
Issue number4
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Medicine(all)

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