Interleukin-1 system in CNS stress: Seizures, fever, and neurotrauma

Tamas Bartfai, Manuel Sanchez-Alavez, Siv Andell-Jonsson, Marianne Schultzberg, Annamaria Vezzani, Erik Danielsson, Bruno Conti

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Proteins of the interleukin-1 (IL-1) system include the secreted agonist IL-1β, and the receptor antagonist IL-1ra, both competing for binding to the IL-1 receptor (IL-1R). IL-1β and IL-1ra are highly inducible under different forms of stress, such as excitatory neurotransmitter excess occurring during seizures, in infection and inflammation, and during neurotrauma. In each of these conditions induction of IL-1β precedes that of IL-1ra, resulting in up to 10-20-fold elevation of IL-1β concentrations. Consequently, IL-1β induces the elevation of other proinflammatory molecules, including IL-6, IL-1R1, COX2, and iNOS, as well as of IL-1ra. Elevation of IL-1ra is of key importance for quenching the inflammatory response at the IL-1R1 as part of an autoregulatory loop. In seizures, IL-1ra is a strong anticonvulsant and in IL-1β-dependent fever, a powerful antipyretic. In traumatic brain injury (TBI), the ability of patients to mount an IL-1ra response, as measured in the CSF, strongly correlated with the neurological outcome. Selective induction or pharmacological application of IL-1ra may be sparing neurons in seizures and neurotrauma.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Pages173-177
Number of pages5
Volume1113
DOIs
Publication statusPublished - Oct 2007

Publication series

NameAnnals of the New York Academy of Sciences
Volume1113
ISSN (Print)00778923
ISSN (Electronic)17496632

Keywords

  • Anticonvulsant
  • Fever
  • Interleukin-1 receptor antagonist
  • Interleukin-1β
  • Neurotrauma
  • Seizure

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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