Interleukin-1 type II receptor: A decoy target for IL-1 that is regulated by IL-4

Francesco Colotta, Fabio Re, Marta Muzio, Riccardo Bertini, Nadia Polentarutti, Marina Sironi, Judith G. Giri, Steven K. Dower, John E. Sims, Alberto Mantovani

Research output: Contribution to journalArticlepeer-review

Abstract

Interleukin-1 (IL-1) interacts with cells through two types of binding molecules, IL-1 type I receptor (IL-1R I) and IL-1R II. The function of IL-1R II is unknown. In studies using monoclonal antibodies, IL-1 prolonged the in vitro survival of polymorphonuclear cells (PMN) through IL-1R I, and IL-4 antagonized the action of IL-1 by inducing expression and release of IL-1R II. Dexamethasone also induced expression and release of the IL-1R II in PMN. These results, together with the effect of antibodies to IL-1R on IL-1-induced production of cytokines in monocytes, indicate that IL-1 acts on myelomonocytic cells through IL-1R I and that IL-1R II inhibits IL-1 activity by acting as a decoy target for IL-1. The existence of multiple pathways of regulation emphasizes the need for tight control of IL-1 action.

Original languageEnglish
Pages (from-to)472-475
Number of pages4
JournalScience
Volume261
Issue number5120
Publication statusPublished - Jul 23 1993

ASJC Scopus subject areas

  • General

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