Interleukin-10 and interleukin-6 gene polymorphisms as risk factors for Alzheimer's disease

Beatrice Arosio; Daria Trabattoni; Lorenza Galimberti; Paolo Bucciarelli; Francesca Fasano; Carmen Calabresi; Carlo Lorenzo Cazzullo; Carlo Vergani; Giorgio Annoni; Mario Clerici

doi:10.1016/j.neurobiolaging.2003.10.009

Interleukin-10 and interleukin-6 gene polymorphisms as risk factors for Alzheimer's disease

Beatrice Arosio, Daria Trabattoni, Lorenza Galimberti, Paolo Bucciarelli, Francesca Fasano, Carmen Calabresi, Carlo Lorenzo Cazzullo, Carlo Vergani, Giorgio Annoni, Mario Clerici

Research output: Contribution to journal › Article › peer-review

Abstract

In the pathogenesis of Alzheimer disease (AD), it has been proposed that the anti-inflammatory interleukins such as IL-10 regulate β-amyloid-induced microglial inflammatory responses inhibiting the proinflammatory cytokine IL-6. Since the promoters of the IL-10 and IL-6 genes show single nucleotide polymorphisms (SNPs) (IL-10: -1082 G→A; IL-6: -174 G→C), we investigated these SNPs and cytokine production by peripheral blood mononuclear cells in 65 AD patients and 65 controls (HC). In AD there was a significant increase of the -1082A IL-10 allele (P=0.009) and a decrease of -1082GG genotype (P=0.019). The frequency of the GG IL-6 genotype in AD was lower and the C allele significantly higher (P

Original language	English
Pages (from-to)	1009-1015
Number of pages	7
Journal	Neurobiology of Aging
Volume	25
Issue number	8
DOIs	https://doi.org/10.1016/j.neurobiolaging.2003.10.009
Publication status	Published - Sep 2004

Keywords

Alzheimer's disease
Apolipoprotein E
Inflammation
Interleukin-10
Interleukin-6
Single nucleotide polymorphism
T lymphocytes

ASJC Scopus subject areas

Clinical Neurology
Biological Psychiatry
Developmental Neuroscience
Neurology
Psychology(all)

Access to Document

10.1016/j.neurobiolaging.2003.10.009

Cite this

@article{4cf29b94507a43768c7ba91d0217ee20,

title = "Interleukin-10 and interleukin-6 gene polymorphisms as risk factors for Alzheimer's disease",

abstract = "In the pathogenesis of Alzheimer disease (AD), it has been proposed that the anti-inflammatory interleukins such as IL-10 regulate β-amyloid-induced microglial inflammatory responses inhibiting the proinflammatory cytokine IL-6. Since the promoters of the IL-10 and IL-6 genes show single nucleotide polymorphisms (SNPs) (IL-10: -1082 G→A; IL-6: -174 G→C), we investigated these SNPs and cytokine production by peripheral blood mononuclear cells in 65 AD patients and 65 controls (HC). In AD there was a significant increase of the -1082A IL-10 allele (P=0.009) and a decrease of -1082GG genotype (P=0.019). The frequency of the GG IL-6 genotype in AD was lower and the C allele significantly higher (P",

keywords = "Alzheimer's disease, Apolipoprotein E, Inflammation, Interleukin-10, Interleukin-6, Single nucleotide polymorphism, T lymphocytes",

author = "Beatrice Arosio and Daria Trabattoni and Lorenza Galimberti and Paolo Bucciarelli and Francesca Fasano and Carmen Calabresi and Cazzullo, {Carlo Lorenzo} and Carlo Vergani and Giorgio Annoni and Mario Clerici",

year = "2004",

month = sep,

doi = "10.1016/j.neurobiolaging.2003.10.009",

language = "English",

volume = "25",

pages = "1009--1015",

journal = "Neurobiology of Aging",

issn = "0197-4580",

publisher = "Elsevier Inc.",

number = "8",

}

TY - JOUR

T1 - Interleukin-10 and interleukin-6 gene polymorphisms as risk factors for Alzheimer's disease

AU - Arosio, Beatrice

AU - Trabattoni, Daria

AU - Galimberti, Lorenza

AU - Bucciarelli, Paolo

AU - Fasano, Francesca

AU - Calabresi, Carmen

AU - Cazzullo, Carlo Lorenzo

AU - Vergani, Carlo

AU - Annoni, Giorgio

AU - Clerici, Mario

PY - 2004/9

Y1 - 2004/9

N2 - In the pathogenesis of Alzheimer disease (AD), it has been proposed that the anti-inflammatory interleukins such as IL-10 regulate β-amyloid-induced microglial inflammatory responses inhibiting the proinflammatory cytokine IL-6. Since the promoters of the IL-10 and IL-6 genes show single nucleotide polymorphisms (SNPs) (IL-10: -1082 G→A; IL-6: -174 G→C), we investigated these SNPs and cytokine production by peripheral blood mononuclear cells in 65 AD patients and 65 controls (HC). In AD there was a significant increase of the -1082A IL-10 allele (P=0.009) and a decrease of -1082GG genotype (P=0.019). The frequency of the GG IL-6 genotype in AD was lower and the C allele significantly higher (P

AB - In the pathogenesis of Alzheimer disease (AD), it has been proposed that the anti-inflammatory interleukins such as IL-10 regulate β-amyloid-induced microglial inflammatory responses inhibiting the proinflammatory cytokine IL-6. Since the promoters of the IL-10 and IL-6 genes show single nucleotide polymorphisms (SNPs) (IL-10: -1082 G→A; IL-6: -174 G→C), we investigated these SNPs and cytokine production by peripheral blood mononuclear cells in 65 AD patients and 65 controls (HC). In AD there was a significant increase of the -1082A IL-10 allele (P=0.009) and a decrease of -1082GG genotype (P=0.019). The frequency of the GG IL-6 genotype in AD was lower and the C allele significantly higher (P

KW - Alzheimer's disease

KW - Apolipoprotein E

KW - Inflammation

KW - Interleukin-10

KW - Interleukin-6

KW - Single nucleotide polymorphism

KW - T lymphocytes

UR - http://www.scopus.com/inward/record.url?scp=2942755836&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2942755836&partnerID=8YFLogxK

U2 - 10.1016/j.neurobiolaging.2003.10.009

DO - 10.1016/j.neurobiolaging.2003.10.009

M3 - Article

C2 - 15212825

AN - SCOPUS:2942755836

VL - 25

SP - 1009

EP - 1015

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

IS - 8

ER -

Interleukin-10 and interleukin-6 gene polymorphisms as risk factors for Alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this