Interleukin-10 and interleukin-6 gene polymorphisms as risk factors for Alzheimer's disease

Beatrice Arosio, Daria Trabattoni, Lorenza Galimberti, Paolo Bucciarelli, Francesca Fasano, Carmen Calabresi, Carlo Lorenzo Cazzullo, Carlo Vergani, Giorgio Annoni, Mario Clerici

Research output: Contribution to journalArticlepeer-review

Abstract

In the pathogenesis of Alzheimer disease (AD), it has been proposed that the anti-inflammatory interleukins such as IL-10 regulate β-amyloid-induced microglial inflammatory responses inhibiting the proinflammatory cytokine IL-6. Since the promoters of the IL-10 and IL-6 genes show single nucleotide polymorphisms (SNPs) (IL-10: -1082 G→A; IL-6: -174 G→C), we investigated these SNPs and cytokine production by peripheral blood mononuclear cells in 65 AD patients and 65 controls (HC). In AD there was a significant increase of the -1082A IL-10 allele (P=0.009) and a decrease of -1082GG genotype (P=0.019). The frequency of the GG IL-6 genotype in AD was lower and the C allele significantly higher (P

Original languageEnglish
Pages (from-to)1009-1015
Number of pages7
JournalNeurobiology of Aging
Volume25
Issue number8
DOIs
Publication statusPublished - Sep 2004

Keywords

  • Alzheimer's disease
  • Apolipoprotein E
  • Inflammation
  • Interleukin-10
  • Interleukin-6
  • Single nucleotide polymorphism
  • T lymphocytes

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

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