Interleukin 10 blocks HIV replication in macrophages by inhibiting the autocrine loop of tumor necrosis factor α and interleukin 6 induction of virus

D. Weissman, G. Poli, A. S. Fauci

Research output: Contribution to journalArticlepeer-review

Abstract

Human interleukin 10 is a pleiotropic cytokine capable of suppressing cytokine production from macrophages and T cells; in addition, it exerts complex regulatory effects on CD8+ T cells, natural killer cells, vascular endothelial cells, and B lymphocytes. Levels of IL-10 are elevated in HIV- infected individuals, suggesting that this cytokine may play a role in the suppression of T cell and monocyte/macrophage function typical of HIV disease. In this article, IL-10 blocked HIV-induced tumor necrosis factor α and interleukin 6 secretion and inhibited HIV replication in monocyte- derived macrophages (MDMs). The inhibition by IL-10 was correlated with a block in endogenous TNF-α and IL-6 secretion from HIV-infected MDMs.

Original languageEnglish
Pages (from-to)1199-1206
Number of pages8
JournalAIDS Research and Human Retroviruses
Volume10
Issue number10
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Immunology
  • Virology

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