Interleukin-10 promoter polymorphisms in giant cell arteritis

Luigi Boiardi, Bruno Casali, Enrico Farnetti, Nicolò Pipitone, Davide Nicoli, PierLuigi Macchioni, Luca Cimino, GianLuigi Bajocchi, Maria Grazia Catanoso, Laura Pattacini, Carlo Salvarani

Research output: Contribution to journalArticle

Abstract

Objective. To investigate potential associations between interleukin-10 (IL-10) promoter polymorphisms and susceptibility to, and clinical features of, giant cell arteritis (GCA). Methods. A total of 140 patients with biopsy-proven GCA who were residents of Reggio Emilia, Italy, and 200 population-based controls from the same geographic area were genotyped for promoter polymorphisms of the IL-10 gene, by molecular methods. The patients were subgrouped according to the presence or absence of polymyalgia rheumatica (PMR) and ischemic complications (any or all of the following: vision loss, jaw claudication, cerebrovascular accidents, or aortic arch syndrome). Results. The distribution of the C/A 592 genotype differed significantly between the GCA patients and the controls (Pcorr = 0.003). Carriers of the A592 allele (A/A or C/A) were significantly more frequent among the GCA patients than among the controls (Pcorr = 0.004, odds ratio [OR] 2.0 [95% confidence interval (95% CI) 1.3-3.1]). Homozygosity for the A592 allele was significantly more frequent among the GCA patients than among the controls (Pcorr = 0.002, OR 3.4 [95% CI 1.6-7.2]). The distribution of the A/G1082 genotype was similar in GCA patients and controls. In the haplotype analysis, the frequency of the ATA haplotype was significantly higher in GCA patients than in the controls (P = 0.0001), whereas the frequencies of the ACC and GTA haplotypes were significantly lower (P = 0.0001 for both comparisons). No significant associations were found for comparisons of GCA patients with and those without PMR or GCA patients with and those without ischemic complications. Conclusion. Our findings show that the -592 C/A promoter polymorphism of the IL-10 gene is associated with susceptibility to GCA.

Original languageEnglish
Pages (from-to)4011-4017
Number of pages7
JournalArthritis and Rheumatism
Volume54
Issue number12
DOIs
Publication statusPublished - Dec 2006

Fingerprint

Giant Cell Arteritis
Interleukin-10
Haplotypes
Polymyalgia Rheumatica
Aortic Arch Syndromes
Alleles
Odds Ratio
Genotype
Confidence Intervals
Population Control
Jaw
Italy
Genes
Stroke
Biopsy

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Interleukin-10 promoter polymorphisms in giant cell arteritis. / Boiardi, Luigi; Casali, Bruno; Farnetti, Enrico; Pipitone, Nicolò; Nicoli, Davide; Macchioni, PierLuigi; Cimino, Luca; Bajocchi, GianLuigi; Catanoso, Maria Grazia; Pattacini, Laura; Salvarani, Carlo.

In: Arthritis and Rheumatism, Vol. 54, No. 12, 12.2006, p. 4011-4017.

Research output: Contribution to journalArticle

Boiardi, L, Casali, B, Farnetti, E, Pipitone, N, Nicoli, D, Macchioni, P, Cimino, L, Bajocchi, G, Catanoso, MG, Pattacini, L & Salvarani, C 2006, 'Interleukin-10 promoter polymorphisms in giant cell arteritis', Arthritis and Rheumatism, vol. 54, no. 12, pp. 4011-4017. https://doi.org/10.1002/art.22218
Boiardi, Luigi ; Casali, Bruno ; Farnetti, Enrico ; Pipitone, Nicolò ; Nicoli, Davide ; Macchioni, PierLuigi ; Cimino, Luca ; Bajocchi, GianLuigi ; Catanoso, Maria Grazia ; Pattacini, Laura ; Salvarani, Carlo. / Interleukin-10 promoter polymorphisms in giant cell arteritis. In: Arthritis and Rheumatism. 2006 ; Vol. 54, No. 12. pp. 4011-4017.
@article{63d3520309a44c5dbcf88bcb8fd2984a,
title = "Interleukin-10 promoter polymorphisms in giant cell arteritis",
abstract = "Objective. To investigate potential associations between interleukin-10 (IL-10) promoter polymorphisms and susceptibility to, and clinical features of, giant cell arteritis (GCA). Methods. A total of 140 patients with biopsy-proven GCA who were residents of Reggio Emilia, Italy, and 200 population-based controls from the same geographic area were genotyped for promoter polymorphisms of the IL-10 gene, by molecular methods. The patients were subgrouped according to the presence or absence of polymyalgia rheumatica (PMR) and ischemic complications (any or all of the following: vision loss, jaw claudication, cerebrovascular accidents, or aortic arch syndrome). Results. The distribution of the C/A 592 genotype differed significantly between the GCA patients and the controls (Pcorr = 0.003). Carriers of the A592 allele (A/A or C/A) were significantly more frequent among the GCA patients than among the controls (Pcorr = 0.004, odds ratio [OR] 2.0 [95{\%} confidence interval (95{\%} CI) 1.3-3.1]). Homozygosity for the A592 allele was significantly more frequent among the GCA patients than among the controls (Pcorr = 0.002, OR 3.4 [95{\%} CI 1.6-7.2]). The distribution of the A/G1082 genotype was similar in GCA patients and controls. In the haplotype analysis, the frequency of the ATA haplotype was significantly higher in GCA patients than in the controls (P = 0.0001), whereas the frequencies of the ACC and GTA haplotypes were significantly lower (P = 0.0001 for both comparisons). No significant associations were found for comparisons of GCA patients with and those without PMR or GCA patients with and those without ischemic complications. Conclusion. Our findings show that the -592 C/A promoter polymorphism of the IL-10 gene is associated with susceptibility to GCA.",
author = "Luigi Boiardi and Bruno Casali and Enrico Farnetti and Nicol{\`o} Pipitone and Davide Nicoli and PierLuigi Macchioni and Luca Cimino and GianLuigi Bajocchi and Catanoso, {Maria Grazia} and Laura Pattacini and Carlo Salvarani",
year = "2006",
month = "12",
doi = "10.1002/art.22218",
language = "English",
volume = "54",
pages = "4011--4017",
journal = "Arthritis care and research : the official journal of the Arthritis Health Professions Association",
issn = "0893-7524",
publisher = "John Wiley and Sons Inc.",
number = "12",

}

TY - JOUR

T1 - Interleukin-10 promoter polymorphisms in giant cell arteritis

AU - Boiardi, Luigi

AU - Casali, Bruno

AU - Farnetti, Enrico

AU - Pipitone, Nicolò

AU - Nicoli, Davide

AU - Macchioni, PierLuigi

AU - Cimino, Luca

AU - Bajocchi, GianLuigi

AU - Catanoso, Maria Grazia

AU - Pattacini, Laura

AU - Salvarani, Carlo

PY - 2006/12

Y1 - 2006/12

N2 - Objective. To investigate potential associations between interleukin-10 (IL-10) promoter polymorphisms and susceptibility to, and clinical features of, giant cell arteritis (GCA). Methods. A total of 140 patients with biopsy-proven GCA who were residents of Reggio Emilia, Italy, and 200 population-based controls from the same geographic area were genotyped for promoter polymorphisms of the IL-10 gene, by molecular methods. The patients were subgrouped according to the presence or absence of polymyalgia rheumatica (PMR) and ischemic complications (any or all of the following: vision loss, jaw claudication, cerebrovascular accidents, or aortic arch syndrome). Results. The distribution of the C/A 592 genotype differed significantly between the GCA patients and the controls (Pcorr = 0.003). Carriers of the A592 allele (A/A or C/A) were significantly more frequent among the GCA patients than among the controls (Pcorr = 0.004, odds ratio [OR] 2.0 [95% confidence interval (95% CI) 1.3-3.1]). Homozygosity for the A592 allele was significantly more frequent among the GCA patients than among the controls (Pcorr = 0.002, OR 3.4 [95% CI 1.6-7.2]). The distribution of the A/G1082 genotype was similar in GCA patients and controls. In the haplotype analysis, the frequency of the ATA haplotype was significantly higher in GCA patients than in the controls (P = 0.0001), whereas the frequencies of the ACC and GTA haplotypes were significantly lower (P = 0.0001 for both comparisons). No significant associations were found for comparisons of GCA patients with and those without PMR or GCA patients with and those without ischemic complications. Conclusion. Our findings show that the -592 C/A promoter polymorphism of the IL-10 gene is associated with susceptibility to GCA.

AB - Objective. To investigate potential associations between interleukin-10 (IL-10) promoter polymorphisms and susceptibility to, and clinical features of, giant cell arteritis (GCA). Methods. A total of 140 patients with biopsy-proven GCA who were residents of Reggio Emilia, Italy, and 200 population-based controls from the same geographic area were genotyped for promoter polymorphisms of the IL-10 gene, by molecular methods. The patients were subgrouped according to the presence or absence of polymyalgia rheumatica (PMR) and ischemic complications (any or all of the following: vision loss, jaw claudication, cerebrovascular accidents, or aortic arch syndrome). Results. The distribution of the C/A 592 genotype differed significantly between the GCA patients and the controls (Pcorr = 0.003). Carriers of the A592 allele (A/A or C/A) were significantly more frequent among the GCA patients than among the controls (Pcorr = 0.004, odds ratio [OR] 2.0 [95% confidence interval (95% CI) 1.3-3.1]). Homozygosity for the A592 allele was significantly more frequent among the GCA patients than among the controls (Pcorr = 0.002, OR 3.4 [95% CI 1.6-7.2]). The distribution of the A/G1082 genotype was similar in GCA patients and controls. In the haplotype analysis, the frequency of the ATA haplotype was significantly higher in GCA patients than in the controls (P = 0.0001), whereas the frequencies of the ACC and GTA haplotypes were significantly lower (P = 0.0001 for both comparisons). No significant associations were found for comparisons of GCA patients with and those without PMR or GCA patients with and those without ischemic complications. Conclusion. Our findings show that the -592 C/A promoter polymorphism of the IL-10 gene is associated with susceptibility to GCA.

UR - http://www.scopus.com/inward/record.url?scp=33845633733&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33845633733&partnerID=8YFLogxK

U2 - 10.1002/art.22218

DO - 10.1002/art.22218

M3 - Article

C2 - 17133531

AN - SCOPUS:33845633733

VL - 54

SP - 4011

EP - 4017

JO - Arthritis care and research : the official journal of the Arthritis Health Professions Association

JF - Arthritis care and research : the official journal of the Arthritis Health Professions Association

SN - 0893-7524

IS - 12

ER -