Interleukin 12 potentiates the curative effect of a vaccine based on interleukin 2-transduced tumor cells

Maddalena Vagliani, Monica Rodolfo, Federica Cavallo, Mariella Parenza, Cecilia Melani, Giorgio Parmiani, Guido Forni, Mario P. Colombo

Research output: Contribution to journalArticlepeer-review

Abstract

The purpose of these studies was to determine whether systemic administration of recombinant interleukin 12 (rIL-12) is able to potentiate an initial, but insufficient T-cell antitumor response. Mice challenged with carcinoma cells engineered to release interleukin 2 (IL-2) and displaying such a response received single or multiple i.p. injections of rIL-12. This combination of systemic rIL-12 and local IL-2 increased the percentage of mice that rejected two different IL-2 gene-transduced tumors. In another set of experiments more closely resembling a clinical situation, IL-2 gene- transduced tumors were used as vaccines in an attempt to cure mice hearing wild-type parental tumors. The combination of these vaccines with systemic rIL-12 cured mice more effectively than rIL-12 and IL-2 gene-transduced tumor vaccines alone.

Original languageEnglish
Pages (from-to)467-470
Number of pages4
JournalCancer Research
Volume56
Issue number3
Publication statusPublished - Feb 1 1996

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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