TY - JOUR
T1 - Interleukin-12 receptor β2
T2 - From cytokine receptor to gatekeeper gene in human B-cell malignancies
AU - Pistoia, Vito
AU - Cocco, Claudia
AU - Airoldi, Irma
PY - 2009/10/1
Y1 - 2009/10/1
N2 - Interleukin (IL) -12 is a cytokine that has been extensively characterized for its immunoregulatory activities. IL-12 binds to a heterodimeric receptor composed of the β1 and β2 chains. In this review article, we discuss recent findings on the expression and function of IL-12 receptor (IL-12R) in malignant B cells frozen at various stages of differentiation and in their normal counterparts. These studies, together with others performed in Il12rb2 knockout mice, have established the concept that the IL-12Rβ2 gene is a gatekeeper from cancer. We will delineate three paradigms reflecting the differential expression of IL-12Rβ2 in different groups of malignant B cells and discuss the therapeutic perspectives stemming from these studies.
AB - Interleukin (IL) -12 is a cytokine that has been extensively characterized for its immunoregulatory activities. IL-12 binds to a heterodimeric receptor composed of the β1 and β2 chains. In this review article, we discuss recent findings on the expression and function of IL-12 receptor (IL-12R) in malignant B cells frozen at various stages of differentiation and in their normal counterparts. These studies, together with others performed in Il12rb2 knockout mice, have established the concept that the IL-12Rβ2 gene is a gatekeeper from cancer. We will delineate three paradigms reflecting the differential expression of IL-12Rβ2 in different groups of malignant B cells and discuss the therapeutic perspectives stemming from these studies.
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U2 - 10.1200/JCO.2008.21.3579
DO - 10.1200/JCO.2008.21.3579
M3 - Article
C2 - 19720917
AN - SCOPUS:70350439428
VL - 27
SP - 4809
EP - 4816
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
SN - 0732-183X
IS - 28
ER -