Interleukin-12 receptor β2: From cytokine receptor to gatekeeper gene in human B-cell malignancies

Vito Pistoia, Claudia Cocco, Irma Airoldi

Research output: Contribution to journalArticlepeer-review

Abstract

Interleukin (IL) -12 is a cytokine that has been extensively characterized for its immunoregulatory activities. IL-12 binds to a heterodimeric receptor composed of the β1 and β2 chains. In this review article, we discuss recent findings on the expression and function of IL-12 receptor (IL-12R) in malignant B cells frozen at various stages of differentiation and in their normal counterparts. These studies, together with others performed in Il12rb2 knockout mice, have established the concept that the IL-12Rβ2 gene is a gatekeeper from cancer. We will delineate three paradigms reflecting the differential expression of IL-12Rβ2 in different groups of malignant B cells and discuss the therapeutic perspectives stemming from these studies.

Original languageEnglish
Pages (from-to)4809-4816
Number of pages8
JournalJournal of Clinical Oncology
Volume27
Issue number28
DOIs
Publication statusPublished - Oct 1 2009

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

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