Interleukin-16 expression and release in bullous pemphigoid

Alessandra Frezzolini, G. Cianchini, M. Ruffelli, S. Cadoni, P. Puddu, O. De Pità

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Cutaneous infiltration of activated CD4+ T cells and eosinophils is an early event in blister formation during bullous pemphigoid (BP), suggesting that the trafficking of circulating leucocytes through the sites of inflammation, their activation and cytokine release is crucial in the pathogenesis of the disease. IL-16 is a major chemotactic factor able to recruit CD4+ cells in the skin during inflammation and to induce the expression of functional high-affinity interleukin (IL)-2 receptors, thus contributing to cellular activation and proliferation. We performed a study in order to evaluate the presence of IL-16 in skin samples and sera and blister fluids of patients affected with BP in active phase of the disease (n = 39), compared with healthy donors studied as control group. Ten patients were also evaluated before and after steroid therapy. Our results demonstrated that IL-16 was expressed strongly by keratinocytes and by dermal infiltrating CD4 + T lymphocytes in lesional skin of BP patients. High levels of IL-16 were detected in sera and blisters of BP, significantly higher in respect to healthy donors. When patients were investigated for the presence of eosinophil cationic protein (ECP) and soluble CD30 (sCD30) to reveal signs of eosinophils and Th2-cells activation, we found a positive correlation between IL-16 serum levels and both ECP and sCD30, suggesting that IL-16 is involved in Th2 lymphocytes and eosinophils recruitment during BP.

Original languageEnglish
Pages (from-to)595-600
Number of pages6
JournalClinical and Experimental Immunology
Volume137
Issue number3
DOIs
Publication statusPublished - Sep 2004

Fingerprint

Interleukin-16
Bullous Pemphigoid
Blister
Skin
Eosinophils
Eosinophil Cationic Protein
Serum
Tissue Donors
Inflammation
T-Lymphocytes
Th2 Cells
Interleukin-2 Receptors
Chemotactic Factors
Keratinocytes
Leukocytes
Steroids
Cell Proliferation
Lymphocytes
Cytokines
Control Groups

Keywords

  • Bullous pemphigoid
  • IL-16

ASJC Scopus subject areas

  • Immunology

Cite this

Frezzolini, A., Cianchini, G., Ruffelli, M., Cadoni, S., Puddu, P., & De Pità, O. (2004). Interleukin-16 expression and release in bullous pemphigoid. Clinical and Experimental Immunology, 137(3), 595-600. https://doi.org/10.1111/j.1365-2249.2004.02570.x

Interleukin-16 expression and release in bullous pemphigoid. / Frezzolini, Alessandra; Cianchini, G.; Ruffelli, M.; Cadoni, S.; Puddu, P.; De Pità, O.

In: Clinical and Experimental Immunology, Vol. 137, No. 3, 09.2004, p. 595-600.

Research output: Contribution to journalArticle

Frezzolini, A, Cianchini, G, Ruffelli, M, Cadoni, S, Puddu, P & De Pità, O 2004, 'Interleukin-16 expression and release in bullous pemphigoid', Clinical and Experimental Immunology, vol. 137, no. 3, pp. 595-600. https://doi.org/10.1111/j.1365-2249.2004.02570.x
Frezzolini A, Cianchini G, Ruffelli M, Cadoni S, Puddu P, De Pità O. Interleukin-16 expression and release in bullous pemphigoid. Clinical and Experimental Immunology. 2004 Sep;137(3):595-600. https://doi.org/10.1111/j.1365-2249.2004.02570.x
Frezzolini, Alessandra ; Cianchini, G. ; Ruffelli, M. ; Cadoni, S. ; Puddu, P. ; De Pità, O. / Interleukin-16 expression and release in bullous pemphigoid. In: Clinical and Experimental Immunology. 2004 ; Vol. 137, No. 3. pp. 595-600.
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