Interleukin-18, interleukin-12B and interferon-γ gene polymorphisms in Brazilian patients with rheumatoid arthritis: A pilot study

H. D. Angelo, I. I F Gomes Silva, R. D R Oliveira, P. Louzada-Júnior, E. A. Donadi, S. Crovella, M. M D Maia, P. R E de Souza, P. Sandrin-Garcia

Research output: Contribution to journalArticle

Abstract

Polymorphisms in interleukin (IL)-18, IL-12 and interferon (IFN)-γ genes are associated with different levels of cytokines expression and have been associated with rheumatoid arthritis (RA). IL-18 +105 A/C, IL-12B +1188 A/C and IFN-γ +874 T/A polymorphisms were analyzed by restriction fragment length polymorphism-polymerase chain reaction (PCR) and amplification refractory mutation system PCR from 90 RA patients and 186 healthy individuals. There were significant differences to IL-18 +105 A/C polymorphism between the RA and control groups (odds ratio=3.77; P

Original languageEnglish
Pages (from-to)276-278
Number of pages3
JournalTissue Antigens
Volume86
Issue number4
DOIs
Publication statusPublished - Oct 1 2015

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Keywords

  • Arthritis
  • Cytokines
  • Polymorphism
  • Rheumatoid

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Genetics

Cite this

Angelo, H. D., Gomes Silva, I. I. F., Oliveira, R. D. R., Louzada-Júnior, P., Donadi, E. A., Crovella, S., Maia, M. M. D., de Souza, P. R. E., & Sandrin-Garcia, P. (2015). Interleukin-18, interleukin-12B and interferon-γ gene polymorphisms in Brazilian patients with rheumatoid arthritis: A pilot study. Tissue Antigens, 86(4), 276-278. https://doi.org/10.1111/tan.12645