Interleukin-18, interleukin-12B and interferon-γ gene polymorphisms in Brazilian patients with rheumatoid arthritis: A pilot study

H. D. Angelo; I. I F Gomes Silva; R. D R Oliveira; P. Louzada-Júnior; E. A. Donadi; S. Crovella; M. M D Maia; P. R E de Souza; P. Sandrin-Garcia

doi:10.1111/tan.12645

Interleukin-18, interleukin-12B and interferon-γ gene polymorphisms in Brazilian patients with rheumatoid arthritis: A pilot study

H. D. Angelo, I. I F Gomes Silva, R. D R Oliveira, P. Louzada-Júnior, E. A. Donadi, S. Crovella, M. M D Maia, P. R E de Souza, P. Sandrin-Garcia

IRCCS pediatrico Burlo Garofolo

Research output: Contribution to journal › Article

Abstract

Polymorphisms in interleukin (IL)-18, IL-12 and interferon (IFN)-γ genes are associated with different levels of cytokines expression and have been associated with rheumatoid arthritis (RA). IL-18 +105 A/C, IL-12B +1188 A/C and IFN-γ +874 T/A polymorphisms were analyzed by restriction fragment length polymorphism-polymerase chain reaction (PCR) and amplification refractory mutation system PCR from 90 RA patients and 186 healthy individuals. There were significant differences to IL-18 +105 A/C polymorphism between the RA and control groups (odds ratio=3.77; P

Original language	English
Pages (from-to)	276-278
Number of pages	3
Journal	Tissue Antigens
Volume	86
Issue number	4
DOIs	https://doi.org/10.1111/tan.12645
Publication status	Published - Oct 1 2015

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Keywords

Arthritis
Cytokines
Polymorphism
Rheumatoid

ASJC Scopus subject areas

Immunology
Immunology and Allergy
Genetics

Cite this

Angelo, H. D., Gomes Silva, I. I. F., Oliveira, R. D. R., Louzada-Júnior, P., Donadi, E. A., Crovella, S., Maia, M. M. D., de Souza, P. R. E., & Sandrin-Garcia, P. (2015). Interleukin-18, interleukin-12B and interferon-γ gene polymorphisms in Brazilian patients with rheumatoid arthritis: A pilot study. Tissue Antigens, 86(4), 276-278. https://doi.org/10.1111/tan.12645

Interleukin-18, interleukin-12B and interferon-γ gene polymorphisms in Brazilian patients with rheumatoid arthritis : A pilot study. / Angelo, H. D.; Gomes Silva, I. I F; Oliveira, R. D R; Louzada-Júnior, P.; Donadi, E. A.; Crovella, S.; Maia, M. M D; de Souza, P. R E; Sandrin-Garcia, P.

In: Tissue Antigens, Vol. 86, No. 4, 01.10.2015, p. 276-278.

Research output: Contribution to journal › Article

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10.1111/tan.12645