Abstract
Polymorphisms in interleukin (IL)-18, IL-12 and interferon (IFN)-γ genes are associated with different levels of cytokines expression and have been associated with rheumatoid arthritis (RA). IL-18 +105 A/C, IL-12B +1188 A/C and IFN-γ +874 T/A polymorphisms were analyzed by restriction fragment length polymorphism-polymerase chain reaction (PCR) and amplification refractory mutation system PCR from 90 RA patients and 186 healthy individuals. There were significant differences to IL-18 +105 A/C polymorphism between the RA and control groups (odds ratio=3.77; P
Original language | English |
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Pages (from-to) | 276-278 |
Number of pages | 3 |
Journal | Tissue Antigens |
Volume | 86 |
Issue number | 4 |
DOIs | |
Publication status | Published - Oct 1 2015 |
Keywords
- Arthritis
- Cytokines
- Polymorphism
- Rheumatoid
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
- Genetics