Interleukin-18 produced by peripheral blood cells is increased in Alzheimer's disease and correlates with cognitive impairment

Paola Bossù, Antonio Ciaramella, Francesca Salani, Federica Bizzoni, Erika Varsi, Fulvia Di Iulio, Franco Giubilei, Walter Gianni, Alberto Trequattrini, Maria Luisa Moro, Sergio Bernardini, Carlo Caltagirone, Gianfranco Spalletta

Research output: Contribution to journalArticle

Abstract

A body of evidence indicates that inflammation plays a pivotal role in AD pathogenesis. IL-18 is a pro-inflammatory cytokine produced in the brain, emerging to be implicated in AD. Although no differences in circulating IL-18 levels were measured between AD patients and controls, a significant increased production of IL-18 was obtained from stimulated blood mononuclear cells of AD patients. This was true particularly in AD subjects carrying the C/C genotype at the -607 position of IL-18 gene promoter. Furthermore, a significant correlation between IL-18 production and cognitive decline was observed in AD patients. Overall, these data indicate that IL-18-related inflammatory pathways, probably also in virtue of polymorphic IL-18 gene influence, are exacerbated in AD patients, and that this cytokine may indeed participate in pathogenic processes leading to dementia.

Original languageEnglish
Pages (from-to)487-492
Number of pages6
JournalBrain, Behavior, and Immunity
Volume22
Issue number4
DOIs
Publication statusPublished - May 2008

Keywords

  • Alzheimer's disease
  • Cognitive decline
  • Interleukin-18

ASJC Scopus subject areas

  • Immunology
  • Behavioral Neuroscience
  • Endocrine and Autonomic Systems

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