Interleukin-1B polymorphism is associated with age at onset of Alzheimer's disease

F. L. Sciacca, C. Ferri, F. Licastro, F. Veglia, I. Biunno, A. Gavazzi, E. Calabrese, F. Martinelli Boneschi, S. Sorbi, C. Mariani, M. Franceschi, L. M E Grimaldi

Research output: Contribution to journalArticlepeer-review


Interleukin-1α (IL-1α) and IL-1β are two pro-inflammatory cytokines involved in the pathogenesis of Alzheimer's disease (AD). The genes coding for IL-1α (IL-1A) and for IL-1β (IL-1B) are clustered in chromosome 2q14-2q14.2. In a previous work, we investigated the role of IL-1A promoter polymorphism (-889 position) in AD pathogenesis: IL-1A -889 TT genotype was associated with sporadic early onset AD. We now report the study on polymorphism of exon 5 IL-1B in position +3953, the nearest polymorphism to -889 IL-1A. We found that the genotype distribution of IL-1B +3953 varied significantly between patients with early and late onset of AD (P

Original languageEnglish
Pages (from-to)927-931
Number of pages5
JournalNeurobiology of Aging
Issue number7
Publication statusPublished - Nov 2003


  • Alzheimer's disease
  • Interleukin-1
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)


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