Interleukin-1beta and interferon-gamma induce proliferation and apoptosis in cultured Schwann cells

Giancarlo Conti; Anto De Pol; Elio Scarpini; Fabiana Vaccina; Milena De Riz; PierLuigi Baron; Marco Tiriticco; Guglielmo Scarlato

doi:10.1016/S0165-5728(02)00003-6

Interleukin-1beta and interferon-gamma induce proliferation and apoptosis in cultured Schwann cells

Giancarlo Conti, Anto De Pol, Elio Scarpini, Fabiana Vaccina, Milena De Riz, PierLuigi Baron, Marco Tiriticco, Guglielmo Scarlato

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

This study reports that in Schwann cell tissue culture the administration of the two pro-inflammatory cytokines, interleukin-1beta (IL-1β) and interferon-gamma (IFN-γ), at different dosages, singly or in combination, can induce apoptosis and/or mitosis. Schwann cell apoptosis was maximal within 24 h of stimulation with 50 U/ml of IFN-γ, while proliferation was at its peak within 24 h with 10 U/ml IL-1β, and both processes decreased progressively by 48 and 72 h. Moreover, the combination of the two cytokines did not show any synergistic effect. These data can be interpreted as a possible involvement of pro-inflammatory cytokines not only in myelin disruption but also in promoting remyelination.

Original language	English
Pages (from-to)	29-35
Number of pages	7
Journal	Journal of Neuroimmunology
Volume	124
Issue number	1-2
DOIs	https://doi.org/10.1016/S0165-5728(02)00003-6
Publication status	Published - 2002

Keywords

Apoptosis
Demyelination
Interferon-gamma
Interleukin-1beta
Peripheral nerve
Schwann cell

ASJC Scopus subject areas

Immunology
Immunology and Allergy
Clinical Neurology
Neurology

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10.1016/S0165-5728(02)00003-6

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Interleukin-1beta and interferon-gamma induce proliferation and apoptosis in cultured Schwann cells. / Conti, Giancarlo; De Pol, Anto; Scarpini, Elio; Vaccina, Fabiana; De Riz, Milena; Baron, PierLuigi; Tiriticco, Marco; Scarlato, Guglielmo.

In: Journal of Neuroimmunology, Vol. 124, No. 1-2, 2002, p. 29-35.

Research output: Contribution to journal › Article › peer-review

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abstract = "This study reports that in Schwann cell tissue culture the administration of the two pro-inflammatory cytokines, interleukin-1beta (IL-1β) and interferon-gamma (IFN-γ), at different dosages, singly or in combination, can induce apoptosis and/or mitosis. Schwann cell apoptosis was maximal within 24 h of stimulation with 50 U/ml of IFN-γ, while proliferation was at its peak within 24 h with 10 U/ml IL-1β, and both processes decreased progressively by 48 and 72 h. Moreover, the combination of the two cytokines did not show any synergistic effect. These data can be interpreted as a possible involvement of pro-inflammatory cytokines not only in myelin disruption but also in promoting remyelination.",

keywords = "Apoptosis, Demyelination, Interferon-gamma, Interleukin-1beta, Peripheral nerve, Schwann cell",

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AU - Conti, Giancarlo

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AU - Scarpini, Elio

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AU - De Riz, Milena

AU - Baron, PierLuigi

AU - Tiriticco, Marco

AU - Scarlato, Guglielmo

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