Abstract
This study reports that in Schwann cell tissue culture the administration of the two pro-inflammatory cytokines, interleukin-1beta (IL-1β) and interferon-gamma (IFN-γ), at different dosages, singly or in combination, can induce apoptosis and/or mitosis. Schwann cell apoptosis was maximal within 24 h of stimulation with 50 U/ml of IFN-γ, while proliferation was at its peak within 24 h with 10 U/ml IL-1β, and both processes decreased progressively by 48 and 72 h. Moreover, the combination of the two cytokines did not show any synergistic effect. These data can be interpreted as a possible involvement of pro-inflammatory cytokines not only in myelin disruption but also in promoting remyelination.
Original language | English |
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Pages (from-to) | 29-35 |
Number of pages | 7 |
Journal | Journal of Neuroimmunology |
Volume | 124 |
Issue number | 1-2 |
DOIs | |
Publication status | Published - 2002 |
Keywords
- Apoptosis
- Demyelination
- Interferon-gamma
- Interleukin-1beta
- Peripheral nerve
- Schwann cell
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
- Clinical Neurology
- Neurology