Interleukin-1beta and interferon-gamma induce proliferation and apoptosis in cultured Schwann cells

Giancarlo Conti, Anto De Pol, Elio Scarpini, Fabiana Vaccina, Milena De Riz, PierLuigi Baron, Marco Tiriticco, Guglielmo Scarlato

Research output: Contribution to journalArticlepeer-review

Abstract

This study reports that in Schwann cell tissue culture the administration of the two pro-inflammatory cytokines, interleukin-1beta (IL-1β) and interferon-gamma (IFN-γ), at different dosages, singly or in combination, can induce apoptosis and/or mitosis. Schwann cell apoptosis was maximal within 24 h of stimulation with 50 U/ml of IFN-γ, while proliferation was at its peak within 24 h with 10 U/ml IL-1β, and both processes decreased progressively by 48 and 72 h. Moreover, the combination of the two cytokines did not show any synergistic effect. These data can be interpreted as a possible involvement of pro-inflammatory cytokines not only in myelin disruption but also in promoting remyelination.

Original languageEnglish
Pages (from-to)29-35
Number of pages7
JournalJournal of Neuroimmunology
Volume124
Issue number1-2
DOIs
Publication statusPublished - 2002

Keywords

  • Apoptosis
  • Demyelination
  • Interferon-gamma
  • Interleukin-1beta
  • Peripheral nerve
  • Schwann cell

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Clinical Neurology
  • Neurology

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