Interleukin-1beta and interleukin-6 release by peripheral blood monocytes in head and neck cancer

O. Gallo, A. M. Gori, M. Attanasio, F. Martini, B. Giusti, M. Boddi, E. Gallina, O. Fini, R. Abbate

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Abstract

In patients with advanced head and neck squamous cell carcinoma (HNSC), evidence of cell-mediated immunity and monocyte functional abnormalities has been reported. We studied the production of interleukin 1 beta (IL-lbeta) and interleukin 6 (IL-6) by peripheral blood monocytes from 22 patients with HNSC (12 larynx and ten oral cavity cancers) in comparison with monocyte cytokine production of age-matched healthy subjects. Pure monocytes were incubated with and without lipopolysaccarides (LPS) (10 μg ml-1) for 4 h at 37°C and IL-lbeta and IL-6 concentrations were determined in supernatants by specific ELISA. There was no significant difference in IL-Ibeta levels in monocyte supernatants from cancer in comparison to control subjects; conversely, a higher IL-6 production by unstimulated and LPS-activated cells from HNSC patients than from controls was found. No relationship was observed between cytokine production and cancer stage. The regression analysis evidenced a significant correlation between IL-lbeta and IL-6 monocyte-release in HNSC patients and in controls, so suggesting a possible autocrine control of IL-6 production by other cytokines.

Original languageEnglish
Pages (from-to)465-468
Number of pages4
JournalBritish Journal of Cancer
Volume68
Issue number3
Publication statusPublished - Sep 1993

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Gallo, O., Gori, A. M., Attanasio, M., Martini, F., Giusti, B., Boddi, M., Gallina, E., Fini, O., & Abbate, R. (1993). Interleukin-1beta and interleukin-6 release by peripheral blood monocytes in head and neck cancer. British Journal of Cancer, 68(3), 465-468.