Abstract
As early as 10-15 min after the start of a 30 min interleukin-2 (IL-2) infusion, a rapid, virtually complete disappearance of all natural killer (NK) lymphocyte subpopulations (including both CD3- CD56+ and CD3+ CD56+ cells with either alpha/beta or gamma/delta T-cell receptor) was observed from peripheral blood. In contrast, the number of T lymphocytes (CD3+ CD56-) was unmodified for at least 2 h after IL-2 injection. The IL-2-induced, rapid disappearance from peripheral blood of NK and NK-like lymphocytes may be related to their massive adherence to the activated endothelium. In this regard, IL-2 infusion caused a very rapid rise of tumour necrosis factor-alpha (TNF-α) plasma concentration, whereas other cytokines, such as interferon-gamma (IFN-γ), were induced only at later times. In vitro experiments indicated that IL-2, either alone or better combined with TNF-α, exerts a rapid and selective stimulatory effect on NK adhesion to endothelial cells. On the basis of these findings, we suggest that the activation of NK lymphocytes induced by IL-2, alone or combined with TNF-α, plays a key role in mediating the massive and selective adherence of NK and NK-like cells following IL-2 bolus infusion.
| Original language | English |
|---|---|
| Pages (from-to) | 818-825 |
| Number of pages | 8 |
| Journal | European Journal of Cancer |
| Volume | 28 |
| Issue number | 4-5 |
| DOIs | |
| Publication status | Published - 1992 |
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ASJC Scopus subject areas
- Cancer Research
- Hematology
- Oncology
Cite this
Interleukin-2 bolus therapy induces immediate and selective disappearance from peripheral blood of all lymphocyte subpopulations displaying natural killer activity : Role of cell adhesion to endothelium. / Salvo, Giuseppe; Samoggia, Paola; Masciulli, Rosalba; Boccoli, Giovanni; Allavena, Paola; Mariani, Gualtiero; Bullo, Angela; Montesoro, Elisabetta; Bulgarini, Daniela; Carlini, Paolo; Ruggeri, Enzo Maria; Arena, Maria Grazia; Camagna, Antonio; Testa, Ugo; Calabresi, Federico; Peschle, Cesare.
In: European Journal of Cancer, Vol. 28, No. 4-5, 1992, p. 818-825.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Interleukin-2 bolus therapy induces immediate and selective disappearance from peripheral blood of all lymphocyte subpopulations displaying natural killer activity
T2 - Role of cell adhesion to endothelium
AU - Salvo, Giuseppe
AU - Samoggia, Paola
AU - Masciulli, Rosalba
AU - Boccoli, Giovanni
AU - Allavena, Paola
AU - Mariani, Gualtiero
AU - Bullo, Angela
AU - Montesoro, Elisabetta
AU - Bulgarini, Daniela
AU - Carlini, Paolo
AU - Ruggeri, Enzo Maria
AU - Arena, Maria Grazia
AU - Camagna, Antonio
AU - Testa, Ugo
AU - Calabresi, Federico
AU - Peschle, Cesare
PY - 1992
Y1 - 1992
N2 - As early as 10-15 min after the start of a 30 min interleukin-2 (IL-2) infusion, a rapid, virtually complete disappearance of all natural killer (NK) lymphocyte subpopulations (including both CD3- CD56+ and CD3+ CD56+ cells with either alpha/beta or gamma/delta T-cell receptor) was observed from peripheral blood. In contrast, the number of T lymphocytes (CD3+ CD56-) was unmodified for at least 2 h after IL-2 injection. The IL-2-induced, rapid disappearance from peripheral blood of NK and NK-like lymphocytes may be related to their massive adherence to the activated endothelium. In this regard, IL-2 infusion caused a very rapid rise of tumour necrosis factor-alpha (TNF-α) plasma concentration, whereas other cytokines, such as interferon-gamma (IFN-γ), were induced only at later times. In vitro experiments indicated that IL-2, either alone or better combined with TNF-α, exerts a rapid and selective stimulatory effect on NK adhesion to endothelial cells. On the basis of these findings, we suggest that the activation of NK lymphocytes induced by IL-2, alone or combined with TNF-α, plays a key role in mediating the massive and selective adherence of NK and NK-like cells following IL-2 bolus infusion.
AB - As early as 10-15 min after the start of a 30 min interleukin-2 (IL-2) infusion, a rapid, virtually complete disappearance of all natural killer (NK) lymphocyte subpopulations (including both CD3- CD56+ and CD3+ CD56+ cells with either alpha/beta or gamma/delta T-cell receptor) was observed from peripheral blood. In contrast, the number of T lymphocytes (CD3+ CD56-) was unmodified for at least 2 h after IL-2 injection. The IL-2-induced, rapid disappearance from peripheral blood of NK and NK-like lymphocytes may be related to their massive adherence to the activated endothelium. In this regard, IL-2 infusion caused a very rapid rise of tumour necrosis factor-alpha (TNF-α) plasma concentration, whereas other cytokines, such as interferon-gamma (IFN-γ), were induced only at later times. In vitro experiments indicated that IL-2, either alone or better combined with TNF-α, exerts a rapid and selective stimulatory effect on NK adhesion to endothelial cells. On the basis of these findings, we suggest that the activation of NK lymphocytes induced by IL-2, alone or combined with TNF-α, plays a key role in mediating the massive and selective adherence of NK and NK-like cells following IL-2 bolus infusion.
UR - http://www.scopus.com/inward/record.url?scp=0026555570&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026555570&partnerID=8YFLogxK
U2 - 10.1016/0959-8049(92)90122-I
DO - 10.1016/0959-8049(92)90122-I
M3 - Article
C2 - 1524901
AN - SCOPUS:0026555570
VL - 28
SP - 818
EP - 825
JO - European Journal of Cancer
JF - European Journal of Cancer
SN - 0959-8049
IS - 4-5
ER -