Interleukin-2 inhalation therapy in renal cell cancer: A case report and review of the literature

Girolamo Del Monte, Patrizia Ferroni, Sabrina Mariotti, Emanuela Fossile, Fiorella Guadagni, Mario Roselli

Research output: Contribution to journalArticlepeer-review


Renal cell carcinoma (RCC) is the most common malignancy of the kidney. One third of RCC presents metastatic disease at the time of diagnosis, usually leading to a fatal outcome. Small response rates were seen with most cytotoxic agents including gemcitabine and vinorelbine, whereas systemic therapy with high doses of interleukin 2 (IL-2) has been shown to provide durable complete remissions. However, in consideration of its severe toxicity, IL-2 immunotherapy is restricted to selected patients. Aerosol IL-2 has been introduced as an alternative therapy in cancer patients. However, only very few data are available on its use in patients with pulmonary metastatic RCC. This paper briefly summarizes current clinical experience with the use of inhaled IL-2 therapy, either as a single therapy or in combination with other treatments. In addition, we report on a male patient with pulmonary metastasized RCC who achieved a durable complete response to combined gemcitabine/ vinorelbine and interleukin-2 inhalation therapy.

Original languageEnglish
Pages (from-to)481-488
Number of pages8
JournalIn Vivo
Issue number4
Publication statusPublished - Jul 2008


  • Chemotherapy
  • Interleukin-2
  • Metastatic disease
  • Renal cell cancer

ASJC Scopus subject areas

  • Medicine(all)


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